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Gremlin

Gremlin 詳細

英語名	Gremlin-1	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	Cell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
研究＆開発段階	Phase 2 Clinical

英語名	Gremlin-1
ターゲットの別称	Cell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

Gremlin 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
His Tag (1)Fc Tag (1)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
GR1-H5254	Human	HEK293	Human Gremlin / GREM1 Protein, Fc Tag
GR1-H52H3	Human	HEK293	Human Gremlin / GREM1 Protein, His Tag

総数量2

Gremlinバックグランド

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Gremlin分子の別称

GREM1,CKTSF1B1,DAND2,DRM,PIG2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
TST-003	TST-003	Phase 2 Clinical	Suzhou Transcenta Therapeutics Co Ltd	Colorectal Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours	詳細
Ginisortamab	UCB-6114	Phase 2 Clinical	Ucb Biopharma Srl	Solid tumours	詳細