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ホームページすべての分子GUCY2C
GUCY2C
GUCY2C 詳細
| 英語名 | Heat-stable enterotoxin receptor | 市販薬剤の数 | 1 |
| 治験薬の数 | 9 | ターゲットの別称 | GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL |
| 研究＆開発段階 | Approved | ||
| 英語名 | Heat-stable enterotoxin receptor |
| ターゲットの別称 | GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL |
| 市販薬剤の数 | 1 |
| 治験薬の数 | 9 |
| 研究＆開発段階 | Approved |
GUCY2C 製品リスト
- 属性
Protein (21)Cell (1)Antibody (1)
- 製品ライブラリ
オンライン (22)研究中 (1)
- 種
Human (15)Mouse (4)Cynomolgus (3)Rabbit (1)
- タグ
Fc Tag (4)His Tag (13)Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)- (2)
- マーカー
Unconjugated (8)FITC Labeled (3)Biotin-labeled (4)PE Labeled (2)AF488 Labeled (1)APC Labeled (2)AF647 Labeled (1)AF555 Labeled (1)- (1)
総数量23
- 1
- 2
- 3
GUCY2Cバックグランド
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
GUCY2C分子の別称
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
ライセンシング
| プロジェクト | 薬物タイプ | 治療分野 | 適応症 | ステージ | エリア |
|---|---|---|---|---|---|
| Anti-GCC humanized antibody | Bispecific antibody | Oncology/Cancer | Solid Tumor | Preclinical | Global |
治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| anti-GUCY2C CAR T-cell therapy (Parasol Biotechnology/Anhui provincial cancer hospital) | Phase 1 Clinical | HeFei Parasol Biotech Co Ltd | Colorectal Neoplasms | 詳細 | |
| anti-guanylyl cyclase C CAR-T cell therapy (Legend Biotech) | LCAR-G08T | Phase 1 Clinical | Legend Biotech Corp | Colorectal Neoplasms; Gastrointestinal Neoplasms | 詳細 |
| HD-006 | HD006; HD-006 | Phase 1 Clinical | Huadao (Shanghai) Biopharma Co Ltd | Solid tumours | 詳細 |
| REVO-UWD-01 | REVO-UWD-01; WD 01 | Phase 1 Clinical | Wondercel Therapeutics Co Ltd | Colorectal Neoplasms | 詳細 |
| IM96 CAR-T cell Therapy | IM96 | Phase 1 Clinical | Imunopharm Technology Co Ltd | Colorectal Neoplasms; Digestive System Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms | 詳細 |
| GCC19CART | GCC19CART; LYL273; LYL-273 | Phase 1 Clinical | Innovative Cellular Therapeutics Co Ltd | Colorectal Neoplasms; Rectal Neoplasms | 詳細 |
| Gucy2c cart cell therapy (Innovative Cellular Therapeutics) | Phase 1 Clinical | Innovative Cellular Therapeutics Co Ltd | Digestive System Neoplasms | 詳細 | |
| XKDCT-080 | XKDCT-080 | Clinical | The Affiliated Hospital Of Qingdao University | Colonic Neoplasms; Solid tumours | 詳細 |
| CT-080 | CT-080 | Clinical | Shenzhen Celconta Life Science Co Ltd | Solid tumours | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Plecanatide | SP-304; GCRA | Approved | Synergy Pharmaceuticals Inc | Trulance | United States | Constipation; Chronic idiopathic constipation | Salix Pharmaceuticals | 2017-01-19 | Chronic idiopathic constipation; Constipation; Irritable Bowel Syndrome | 詳細 |
- 詳細
- 製品リスト
- 市販薬剤に関する情報
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