言語を選択

HMGB1

HMGB1 詳細

英語名	High Mobility Group Protein B1	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
研究＆開発段階	Phase 2 Clinical

英語名	High Mobility Group Protein B1
ターゲットの別称	FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 2 Clinical

HMGB1 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (2)Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HM1-H5220	Human	HEK293	Human HMGB1 Protein, His Tag, low endotoxin
HM1-H5255	Human	HEK293	Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin
HM1-H82E3	Human	HEK293	Biotinylated Human HMGB1 Protein, His,Avitag™
HM1-M52H6	Mouse	HEK293	Mouse HMGB1 Protein, His Tag (MALS verified)

総数量4

HMGB1バックグランド

High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.

HMGB1分子の別称

HMGB1,HMG1,HMG3,SBP-1

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
SB-17170	SB-17170	Phase 2 Clinical	Spark Biopharma Inc	Drug-Related Side Effects and Adverse Reactions; Idiopathic Pulmonary Fibrosis; Solid tumours	詳細