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HVEM

HVEM 詳細

英語名	Tumor necrosis factor receptor superfamily member 14	市販薬剤の数	0
治験薬の数	0	ターゲットの別称	Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
研究＆開発段階	Preclinical

英語名	Tumor necrosis factor receptor superfamily member 14
ターゲットの別称	Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
市販薬剤の数	0
治験薬の数	0
研究＆開発段階	Preclinical

HVEM 製品リスト

属性
Protein (4)Cell (3)
製品ライブラリ
オンライン (7)
種
Human (7)
タグ
Fc Tag (1)His Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (3)
マーカー
Unconjugated (3)Biotin-labeled (1)- (3)

製品番号	種	発現システム	製品説明
HOT HVM-H5257	Human	HEK293	Human HVEM / TNFRSF14 Protein, Mouse IgG2a Fc Tag (MALS verified)
HOT HVM-H5258	Human	HEK293	Human HVEM / TNFRSF14 Protein, Fc Tag, low endotoxin (MALS verified)
HOT HVM-H52E9	Human	HEK293	Human HVEM / TNFRSF14 Protein, His Tag (MALS verified)
HOT HVM-H82F6	Human	HEK293	Biotinylated Human HVEM / TNFRSF14 Protein, Fc,Avitag™ (MALS verified)
CHEK-ATF105	Human	HEK293	Human HVEM (Luc) HEK293 Reporter Cell
CHEK-ATP147	Human	HEK293	HEK293/Human HVEM Stable Cell Line
SCRAJ-STF108	Human	Raji	Raji/Human HVEM Stable Cell Line

総数量7

HVEMバックグランド

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.