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IDH1

IDH1 詳細

英語名	Isocitrate dehydrogenase [NADP] cytoplasmic	市販薬剤の数	3
治験薬の数	11	ターゲットの別称	IDH，EC 1.1.1.42，PICD，IDCD，Isocitrate Dehydrogenase (NADP(+)) 1，Isocitrate Dehydrogenase 1 (NADP+)， Soluble，HEL-S-26，IDH1，Isocitrate Dehydrogenase (NADP(+)) 1， Cytosolic，HEL-216，NADP(+)-Specific ICDH，Cytosolic NADP-Isocitrate Dehydrogenase，IDP，NADP-Dependent Isocitrate Dehydrogenase， Cytosolic，Oxalosuccinate Decarboxylase，Epididymis Secretory Protein Li 26，Isocitrate Dehydrogenase 1 (NADP+)，NADP-Dependent Isocitrate Dehydrogenase， Peroxisomal，IDPC，EC:1.1.1.42，Epididymis Luminal Protein 216，Epididymis Secretory Sperm Binding Protein，Isocitrate Dehydrogenase [NADP] Cytoplasmic
研究＆開発段階	Approved

英語名	Isocitrate dehydrogenase [NADP] cytoplasmic
ターゲットの別称	IDH，EC 1.1.1.42，PICD，IDCD，Isocitrate Dehydrogenase (NADP(+)) 1，Isocitrate Dehydrogenase 1 (NADP+)， Soluble，HEL-S-26，IDH1，Isocitrate Dehydrogenase (NADP(+)) 1， Cytosolic，HEL-216，NADP(+)-Specific ICDH，Cytosolic NADP-Isocitrate Dehydrogenase，IDP，NADP-Dependent Isocitrate Dehydrogenase， Cytosolic，Oxalosuccinate Decarboxylase，Epididymis Secretory Protein Li 26，Isocitrate Dehydrogenase 1 (NADP+)，NADP-Dependent Isocitrate Dehydrogenase， Peroxisomal，IDPC，EC:1.1.1.42，Epididymis Luminal Protein 216，Epididymis Secretory Sperm Binding Protein，Isocitrate Dehydrogenase [NADP] Cytoplasmic
市販薬剤の数	3
治験薬の数	11
研究＆開発段階	Approved

IDH1 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
His Tag (2)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
ID1-H51H6	Human	E. coli	Human IDH1 Protein, His Tag (active enzyme, MALS verified)
ID1-H51H8	Human	E. coli	Human IDH1 (R132C) Protein, His Tag (MALS verified)

総数量2

IDH1バックグランド

The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‑ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha‑ketoglutarate，2-HG is elevated in several tumor types, including a subset of AMLs.

IDH1分子の別称

IDH1,PICD,IDP

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Safusidenib	DS-1001b; DS-1001; AB-218	Phase 3 Clinical	Daiichi Sankyo Co Ltd	Astrocytoma; Biliary Tract Neoplasms; Glioblastoma; Glioma; Oligodendroglioma; Solid tumours	詳細
Ranosidenib	HMPL-306	Phase 3 Clinical		Glioma; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Solid tumours	詳細
TQB-3454	TQB-3454; CT-2755	Phase 3 Clinical	Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Bile Duct Neoplasms; Biliary Tract Neoplasms; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Solid tumours	詳細
MT-001	MT-001; MT001	Phase 2 Clinical	Zhejiang Meton Pharmaceutical Co Ltd	Neoplasms; Solid tumours	詳細
BAY-1436032	BAY-1436032	Phase 1 Clinical	Bayer AG	Leukemia, Myeloid, Acute; Solid tumours	詳細
IDH-305	IDH-305	Phase 1 Clinical	Novartis Pharma Ag	Glioma; Leukemia, Myeloid, Acute; Neoplasms	詳細
IDH1/2 inhibitor (Eli Lilly)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	詳細
BPI-221351	BPI-221351	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Glioma; Solid tumours	詳細
KY-100001	KY-100001	Phase 1 Clinical	Kpc Pharmaceuticals Inc	Solid tumours	詳細
HH-2301	HH-2301; HH2301	Phase 1 Clinical	ShangHai HaiHe Biopharma Co Ltd	Biliary Tract Neoplasms; Chondrosarcoma; Glioma; Solid tumours	詳細
LY-3410738	LY-3410738	Phase 1 Clinical	Eli Lilly And Company	Cholangiocarcinoma; Chondrosarcoma; Glioma; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Myeloproliferative Disorders; Solid tumours	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Ivosidenib	CS-3010; S-95031; CS 3010; AG-120	Approved	Agios Pharmaceuticals Inc	拓舒沃, Tidhesco, Tibsovo, TIBSOVO, Tuoshuvo, Tosuvo	United States	Leukemia, Myeloid, Acute	Servier Pharmaceuticals Llc	2018-07-20	Bile Duct Neoplasms; Cholangiocarcinoma; Chondrosarcoma; Ependymoma; Glioma; Hematologic Neoplasms; Hepatic Insufficiency; Hepatoblastoma; Histiocytosis, Langerhans-Cell; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Medulloblastoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Sarcoma, Myeloid; Solid tumours; Wilms Tumor	詳細
Vorasidenib	AG-881; AGI-23088; S-95032; S95032	Approved	Agios Pharmaceuticals Inc	VORANIGO	United States	Astrocytoma; Oligodendroglioma; Glioma	Servier Pharmaceuticals Llc, Laboratoires Servier	2024-08-06	Astrocytoma; Ganglioglioma; Glioblastoma; Glioma; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Liver Diseases; Liver Dysfunction; Myelodysplastic Syndromes; Oligodendroglioma	詳細
Olutasidenib	FT-2102	Approved	Forma Therapeutics Holdings Inc	Rezlidhia	United States	Leukemia, Myeloid, Acute	Rigel Pharmaceuticals Inc	2022-12-01	Chondrosarcoma; Diarrhea; Irritable Bowel Syndrome; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Promyelocytic, Acute; Myelodysplastic Syndromes	詳細