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IDO1

IDO1 詳細

英語名	Indoleamine 2,3-dioxygenase	市販薬剤の数	0
治験薬の数	11	ターゲットの別称	Indoleamine-pyrrole 2，3-dioxygenase，IDO1，IDO-1，INDO，IDO，Indoleamine-Pyrrole 2，3 Dioxygenase，Indole 2，3-Dioxygenase，EC 1.13.11.52，Indoleamine-Pyrrole 2，3，-Dioxygenase，Indoleamine 2，3-Dioxygenase 1，Indolamine 2，3 Dioxygenase，EC:1.13.11.52
研究＆開発段階	Phase 3 Clinical

英語名	Indoleamine 2,3-dioxygenase
ターゲットの別称	Indoleamine-pyrrole 2，3-dioxygenase，IDO1，IDO-1，INDO，IDO，Indoleamine-Pyrrole 2，3 Dioxygenase，Indole 2，3-Dioxygenase，EC 1.13.11.52，Indoleamine-Pyrrole 2，3，-Dioxygenase，Indoleamine 2，3-Dioxygenase 1，Indolamine 2，3 Dioxygenase，EC:1.13.11.52
市販薬剤の数	0
治験薬の数	11
研究＆開発段階	Phase 3 Clinical

IDO1 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
ID1-H5143	Human	E. coli	Human IDO1 Protein, His Tag (active enzyme, MALS verified)

総数量1

IDO1バックグランド

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

IDO1分子の別称

IDO, IDO-1, INDO

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Epacadostat	INCB-024360; 71596A9R13 (UNII code); INCB-24360	Phase 3 Clinical	Incyte Corp	Abdominal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal adenocarcinoma; Esophageal Squamous Cell Carcinoma; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Glioma; Head and Neck Neoplasms; Leukemia, B-Cell; Lung Neoplasms; Lymphoma; Lymphoma, B-Cell; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Skin Melanoma; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Urinary Bladder N	詳細
Puliginurad	YL-90148	Phase 3 Clinical	YL-Pharma	Gout; Hyperuricemia	詳細
Linrodostat	ONO-7701; BMS-986205	Phase 3 Clinical	Bristol-Myers Squibb Company	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Endometrial Neoplasms; Glioblastoma; Head and Neck Neoplasms; Laryngeal Diseases; Lung Neoplasms; Melanoma; Neoplasms; Oral Squamous Cell Carcinoma; Skin Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms	詳細
HTX-201	KHK-2455; HTX-201	Phase 2 Clinical	Kyowa Hakko Kirin Co Ltd	Carcinoma; Carcinoma, Transitional Cell; Epstein-Barr Virus Infections; Neoplasms; Rejection of renal transplantation; Solid tumours	詳細
IO-102	IO-102	Phase 2 Clinical	Herlev Hospital, Io Biotech Aps, Merck Sharp & Dohme Corp	Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Melanoma; Oral Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma (OPSCC)	詳細
(-)-Epigallocatechin gallate	AB-4166	Phase 2 Clinical	Charite Universitaetsmedizin Berlin	Alzheimer Disease; Colonic Neoplasms; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Frailty; Glaucoma, Open-Angle; Huntington Disease; Hypertension; Idiopathic Pulmonary Fibrosis; Inflammation; Insulin Resistance; Leukemia; Liver Cirrhosis; Lung Diseases, Interstitial; Multiple Sclerosis, Relapsing-Remitting; Muscular Dystrophy, Duchenne; Neoplasms; Obesity; Ocular Hypertension; Papillomavirus Infections; Parkinson Disease; Peripheral Nervous System Diseases; Prostatic Neoplasms; Uterine Cervical Diseases	詳細
Indoximod	1-MT; D-1MT; NLG-001; NLG-8189; NSC-721782	Phase 2 Clinical	Newlink Genetics Co	Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Diffuse Intrinsic Pontine Glioma; Ependymoma; Glioblastoma; Glioma; Gliosarcoma; Leukemia, Myeloid, Acute; Lung Neoplasms; Medulloblastoma; Melanoma; Metastatic breast cancer; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours	詳細
RiMO-301	RiMO-301	Phase 2 Clinical	The University Of Chicago	Head and Neck Neoplasms; Neoplasms	詳細
SHR-9146	HTI-1090; SHR-9146	Phase 1 Clinical	Jiangsu Hengrui Medicine Co Ltd	Neoplasms; Solid tumours	詳細
LPM-3480226	LY-01013; LPM-3480226	Phase 1 Clinical	Luye Pharma Group Ltd	Solid tumours	詳細
TQB-3562	TQB-3562	Phase 1 Clinical	Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd	Solid tumours	詳細