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IGF-II R

IGF-II R 詳細

英語名	Insulin-like growth factor II receptor	市販薬剤の数	1
治験薬の数	0	ターゲットの別称	Insulin-like growth factor 2 receptor，IGF-II receptor，CD222，Insulin Like Growth Factor 2 Receptor，M6P/IGF2R，M6P/IGF2 receptor，CI Man-6-P receptor，Insulin-like growth factor II receptor，IGF2R，300 KDa Mannose 6-Phosphate Receptor，MPR 300，MPRI，Cation-Independent Mannose-6-Phosphate Receptor，Cation-Independent Mannose-6 Phosphate Receptor，CD222 Antigen，CI-M6PR，MPR300，CI-MPR，CIMPR，M6P-R，MPR1，M6PR，Receptor， IGF Type 2
研究＆開発段階	Approved

英語名	Insulin-like growth factor II receptor
ターゲットの別称	Insulin-like growth factor 2 receptor，IGF-II receptor，CD222，Insulin Like Growth Factor 2 Receptor，M6P/IGF2R，M6P/IGF2 receptor，CI Man-6-P receptor，Insulin-like growth factor II receptor，IGF2R，300 KDa Mannose 6-Phosphate Receptor，MPR 300，MPRI，Cation-Independent Mannose-6-Phosphate Receptor，Cation-Independent Mannose-6 Phosphate Receptor，CD222 Antigen，CI-M6PR，MPR300，CI-MPR，CIMPR，M6P-R，MPR1，M6PR，Receptor， IGF Type 2
市販薬剤の数	1
治験薬の数	0
研究＆開発段階	Approved

IGF-II R 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
His Tag (2)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
IGR-H52H4	Human	HEK293	Human IGF-II R (43-1365) Protein, His Tag (MALS verified)
IGR-H53H3	Human	CHO	Human IGF-II R Protein, His Tag (MALS verified)

総数量2

IGF-II Rバックグランド

IGF2R, also known as the cation-independent mannose-6-phosphate receptor, is found ubiquitously in human tissues with a truncated soluble form of the receptor present in the circulation. Full-length, 300-kDa, IGF2R comprises a large N-terminal extracellular region of 15 homologous domains, a single membrane-spanning region and a small cytoplasmic tail. In addition to IGF-II binding, major IGF2R functions include sorting newly synthesized lysosomal enzymes and endocytosis of extracellular lysosomal enzymes. To perform these disparate functions, the extracellular region contains binding sites for IGF-II and phosphomannosyl residues

IGF-II R分子の別称

Cation-independent mannose-6-phosphate receptor,CI Man-6-P receptor,CI-MPR,M6PR,300 kDa mannose 6-phosphate receptor (MPR 300),Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor (IGF-II receptor),M6P/IGF2 receptor (M6P/IGF2R),CD2

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Avalglucosidase alfa	neoGAA; GZ-402666; Neo-rhGAA; NeoGAA	Approved	Genzyme Corp	Nexviazyme, Nexviadyme, 耐而赞	United States	Glycogen Storage Disease Type II	Genzyme Corp	2021-08-06	Glycogen Storage Disease Type II	詳細