IgG3 Fc 詳細
Molecule Name
Immunoglobulin G
分子の別称
Ig gamma-3 chain C region,IgG,IgG3
Drug Development Progress
治験薬の数8
市販薬剤の数1
研究＆開発段階Approved
ターゲットの別称
Immunoglobulin G
バックグランド
Immunoglobulin G3 (IgG3) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. Ig gamma-3 chain C region (IgG3-Fc / IGHG3) contains two constant regions of IgG3 H chain (CH2, CH3).
IgG3 Fc 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| Ricefidase | KJ-103; KJ103 | Phase 3 Clinical | Shanghai Bao Pharmaceuticals Co Ltd | Anti-Glomerular Basement Membrane Disease; Guillain-Barre Syndrome; Rejection of renal transplantation | 詳細 |
| AT-02 | AT-02 | Phase 2 Clinical | Attralus Inc | Amyloidosis; Immunoglobulin Light-chain Amyloidosis | 詳細 |
| JZB-34 | AAFP; JZB-34 | Phase 1 Clinical | Shanghai Kexin Biotech Co Ltd | Hypersensitivity | 詳細 |
| Emicizumab biosimilar (Jushi Biopharmaceutical) | SYS6053; SYS-6053 | Phase 1 Clinical | Jushi Biopharmaceutical Co Ltd | Hemophilia A; Hemorrhage | 詳細 |
| S-1117 | S-1117 | Phase 1 Clinical | Seismic Therapeutics Inc | Immune System Diseases | 詳細 |
| BHV-1300 | BHV-1300 | Phase 1 Clinical | Biohaven Pharmaceuticals Inc | Arthritis, Rheumatoid; Graves Disease | 詳細 |
| HNSA-5487 | HNSA 5487; HNSA-5487 | Phase 1 Clinical | Hansa Biopharma Ab | Autoimmune Diseases; Neoplasms | 詳細 |
| Anti-CD33/anti-FcgammaRI bispecific antibody (UCSD) | Phase 1 Clinical | University Of California San Diego | Leukemia, Myeloid, Acute | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Imlifidase | Mac-1 | Approved | Hansamed Inc | Idefirix | EU | Rejection of renal transplantation | Hansa Biopharma Ab | 2020-08-25 | Guillain-Barre Syndrome; Kidney Diseases; Kidney Failure, Chronic; Purpura, Thrombotic Thrombocytopenic; Rejection of renal transplantation; Rejection of organ transplantation; Renal Insufficiency, Chronic | 詳細 |