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IL-1 Rrp2

IL-1 Rrp2 詳細

英語名	Interleukin-36 receptor	市販薬剤の数	1
治験薬の数	4	ターゲットの別称	Interleukin-1 Receptor-Related Protein 2，Interleukin-1 Receptor-Like 2，IL-1Rrp2，Interleukin 1 Receptor Like 2，EC:3.2.2.6，IL-36R，IL1RRP2，IL-36 Receptor，IL1R-Rp2，IL1RL2，IL-1 Receptor-Related Protein 2
研究＆開発段階	Approved

英語名	Interleukin-36 receptor
ターゲットの別称	Interleukin-1 Receptor-Related Protein 2，Interleukin-1 Receptor-Like 2，IL-1Rrp2，Interleukin 1 Receptor Like 2，EC:3.2.2.6，IL-36R，IL1RRP2，IL-36 Receptor，IL1R-Rp2，IL1RL2，IL-1 Receptor-Related Protein 2
市販薬剤の数	1
治験薬の数	4
研究＆開発段階	Approved

IL-1 Rrp2 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (4)Cynomolgus (1)
タグ
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
マーカー
Unconjugated (4)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT IL2-H5254	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 Protein, Fc Tag
HOT IL2-H52H4	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 (C154S, C262S) Protein, His Tag (MALS verified)
HOT IL2-H52H6	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag, low endotoxin
HOT IL2-H82E9	Human	HEK293	Biotinylated Human IL-1 Rrp2 / IL-1 R6 Protein, His,Avitag™
HOT IL2-C52H5	Cynomolgus	HEK293	Cynomolgus IL-1 Rrp2 / IL-1 R6 Protein, His Tag

総数量5

IL-1 Rrp2バックグランド

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-1 Rrp2分子の別称

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
HB-0043	HB-0043	Phase 2 Clinical	HuaBo Biopharm Co Ltd	Acne Vulgaris; Arthritis, Rheumatoid; Autoimmune Diseases; Dermatitis, Atopic; Hidradenitis Suppurativa; Lupus Erythematosus, Systemic; Lupus Nephritis; Psoriasis; Renal Insufficiency, Chronic	詳細
SHR-1139	SHR1139; SHR-1139	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Colitis, Ulcerative; Plaque psoriasis; Psoriasis; Pyoderma Gangrenosum	詳細
TQH-2929	TQH-2929; TQH2929	Phase 2 Clinical	Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group	Generalised pustular psoriasis; Psoriasis; Pustular psoriasis	詳細
IMG-008	IMG008	Phase 1 Clinical	Ikena Oncology Inc	Autoimmune Diseases; Inflammation	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Spesolimab	BI-655130	Approved	C.H. Boehringer Sohn Ag & Co. Kg	圣利卓, Spevigo	United States	Psoriasis	Boehringer Ingelheim Pharmaceuticals Inc	2022-09-01	Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Generalised pustular psoriasis; Hidradenitis Suppurativa; Netherton Syndrome; Palmoplantar pustulosis; Psoriasis; Pyoderma Gangrenosum	詳細