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IL-12B

IL-12B 詳細

英語名	Interleukin-12 subunit beta	市販薬剤の数	8
治験薬の数	2	ターゲットの別称	IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2
研究＆開発段階	Approved

英語名	Interleukin-12 subunit beta
ターゲットの別称	IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2
市販薬剤の数	8
治験薬の数	2
研究＆開発段階	Approved

IL-12B 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (1)Fc Tag (1)His Tag & Avi Tag (2)
マーカー
Unconjugated (2)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT NK2-H82E3	Human	HEK293	Biotinylated Human IL-12B / NKSF2 / p40 Protein, His,Avitag™
NK2-H5258	Human	HEK293	Human IL-12B / NKSF2 / p40 Protein, Fc Tag
NK2-H52H7	Human	HEK293	Human IL-12B / NKSF2 / p40 Protein, His Tag
NK2-M82E5	Mouse	HEK293	Biotinylated Mouse IL-12B / NKSF2 / p40 Protein, His,Avitag™ (MALS verified)

総数量4

IL-12Bバックグランド

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B分子の別称

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
RO-7837195	RO-7837195; RO7837195	Phase 2 Clinical	Genentech Inc	Colitis, Ulcerative	詳細
PF-07261271	RG-6730; PF-07261271	Phase 2 Clinical	Pfizer Inc	Inflammatory Bowel Diseases	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Ustekinumab biosimilar (Bio-Thera)	BAT-2206	Approved	Bio-Thera Solutions Ltd	STARJEMZA, Usymro	United States	Plaque psoriasis; Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic	Bio-Thera Solutions Ltd	2025-05-22	Arthritis, Psoriatic; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	詳細
Ustekinumab	C-340; CNTO-1275	Approved	Johnson & Johnson Innovative Medicine	Stelara, 喜达诺	United States	Plaque psoriasis	Janssen Biotech Inc	2009-09-25	Arthritis, Juvenile; Arthritis, Psoriatic; Colitis, Ulcerative; Common Variable Immunodeficiency; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Diabetes Mellitus, Type 1; Hidradenitis Suppurativa; Ichthyosis; Inflammatory Bowel Diseases; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Multiple Sclerosis; Palmoplantar pustulosis; Pediatric Crohn's disease; Plaque psoriasis; Polymyositis; Pouchitis; Psoriasis; Sjogren's Syndrome; Spondylitis, Ankylosing; Takayasu Arteritis; Type I Leukocyte Adhesion Defect; Uveitis	詳細
Ebdarokimab	AK-101; AK101	Approved		爱达罗	Mainland China	Plaque psoriasis	Zhongshan Akeso Biopharma Co Ltd	2025-04-15	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	詳細
Ustekinumab Biosimilar(Celltrion)	CT-P43	Approved	Celltrion Inc	Steqeyma, Steqeyma IV, Qoyvolma	Canada	Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis	Celltrion Inc	2024-08-01	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	詳細
Ustekinumab biosimilar (Biocon)	Bmab 1200	Approved	Biocon Biologics Ltd	Yesintek	United States	Colitis, Ulcerative; Crohn Disease; Arthritis, Psoriatic	Biocon Biologics Inc	2024-11-29	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	詳細
Ustekinumab biosimilar (Alvotech)	AVT04; AVT-04	Approved	Alvotech hf	Jamteki, Uzpruvo, SELARSDI™, JamtekiTM, Ustekinumab BS (F)	Japan	Arthritis, Psoriatic; Psoriasis	Fuji Pharma Co Ltd	2023-09-25	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	詳細
Ustekinumab biosimilar (Samsung Bioepis)	SB-17; SB17	Approved	Samsung Bioepis Co Ltd	Pyzchiva, Eksunbi	EU	Crohn Disease; Colitis, Ulcerative	Samsung Bioepis Nl Bv	2024-04-19	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Gastrointestinal Diseases; Inflammation; Plaque psoriasis; Psoriasis; Rheumatic Diseases; Skin Diseases	詳細
Ustekinumab biosimilar (Amgen)	ABP-654; AMG-654	Approved	Amgen Inc	Wezlana, WEZLANA, wezenla, WEZENLA	United States	Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis	Amgen Inc	2023-10-31	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	詳細