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IL-17B

IL-17B 詳細

英語名	Interleukin-17 receptor B	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	IL-17 receptor B，IL-17RB，Cytokine receptor-like 4，IL-17 receptor homolog 1，IL-17Rh1，IL17Rh1，Interleukin-17B receptor，IL-17B receptor
研究＆開発段階	Phase 2 Clinical

英語名	Interleukin-17 receptor B
ターゲットの別称	IL-17 receptor B，IL-17RB，Cytokine receptor-like 4，IL-17 receptor homolog 1，IL-17Rh1，IL17Rh1，Interleukin-17B receptor，IL-17B receptor
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 2 Clinical

IL-17B 製品リスト

属性
Protein (3)
製品ライブラリ
オンライン (3)
種
Human (2)Mouse (1)
タグ
Fc Tag (1)Fc Tag & Avi Tag (2)
マーカー
Unconjugated (1)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
ILB-H5257	Human	HEK293	Human IL-17B Protein, Fc Tag (MALS verified)
ILB-H82F1	Human	HEK293	Biotinylated Human IL-17B Protein, Fc,Avitag™ (MALS verified)
ILB-M82F3	Mouse	HEK293	Biotinylated Mouse IL-17B Protein, Fc,Avitag™ (MALS verified)

総数量3

IL-17Bバックグランド

IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.