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IL-1RL1

IL-1RL1 詳細

英語名	Interleukin-1 receptor-like 1	市販薬剤の数	0
治験薬の数	5	ターゲットの別称	ST2，IL1RL1，Protein ST2，DER4，T1，Interleukin 1 Receptor Like 1，Homolog Of Mouse Growth Stimulation-Expressed，Interleukin 1 Receptor-Related Protein，Growth Stimulation-Expressed，FIT-1，IL33R，ST2L，ST2V，Interleukin-1 Receptor-Like 1 Protein，EC:3.2.2.6，Interleukin-1 Receptor-Like 1
研究＆開発段階	NDA/BLA

英語名	Interleukin-1 receptor-like 1
ターゲットの別称	ST2，IL1RL1，Protein ST2，DER4，T1，Interleukin 1 Receptor Like 1，Homolog Of Mouse Growth Stimulation-Expressed，Interleukin 1 Receptor-Related Protein，Growth Stimulation-Expressed，FIT-1，IL33R，ST2L，ST2V，Interleukin-1 Receptor-Like 1 Protein，EC:3.2.2.6，Interleukin-1 Receptor-Like 1
市販薬剤の数	0
治験薬の数	5
研究＆開発段階	NDA/BLA

IL-1RL1 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (4)Mouse (1)
タグ
His Tag (1)Fc Tag (2)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT IL1-H5229	Human	HEK293	Human IL-1RL1 / ST2 Protein, His Tag, low endotoxin (MALS verified)
HOT IL1-H5250	Human	HEK293	Human IL-1RL1 / ST2 Protein, Fc Tag
HOT IL1-H82E9	Human	HEK293	Biotinylated Human IL-1RL1 / ST2 Protein, His,Avitag™ (MALS verified)
HOT IL1-M5259	Mouse	HEK293	Mouse IL-1RL1 / ST2 Protein, Fc Tag
IL1-H82F8	Human	HEK293	Biotinylated Human IL-1RL1 / ST2 Protein, Fc,Avitag™ (MALS verified)

総数量5

IL-1RL1バックグランド

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

IL-1RL1分子の別称

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Astegolimab	AMG-282; RG-6149; RO-7187807	Phase 3 Clinical	Amgen Inc, F. Hoffmann-La Roche Ltd	Coronavirus Disease 2019 (COVID-19); Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive	詳細
AK-139	AK139; AK-139	Phase 2 Clinical	Kangfang Biotechnology (Cayman) Co Ltd	Asthma; Chronic rhinosinusitis with nasal polyps (CRSwNP); Chronic Urticaria; Dermatitis, Atopic; Hypersensitivity; Prurigo Nodularis; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal	詳細
TQC-2938	TQC2938; TQC-2938	Phase 2 Clinical	Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group	Asthma; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Seasonal	詳細
Recombinant humanized anti-ST2 monoclonal antibody	9-MW1911; 9MW-1911; 9-MW-1911; 9MW1911	Phase 2 Clinical	Mabwell (Shanghai) Bioscience Co Ltd	Asthma; Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive	詳細
NEROFE		Phase 1 Clinical	Immune System Key Ltd	Neoplasms; Solid tumours	詳細