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IL-2

IL-2 詳細

英語名	Interleukin-2	市販薬剤の数	2
治験薬の数	43	ターゲットの別称	T-cell growth factor，IL2，Interleukin 2，T Cell Growth Factor，Aldesleukin，IL-2，TCGF，Involved In Regulation Of T-Cell Clonal Expansion，Interleukin-2，Lymphokine
研究＆開発段階	Approved

英語名	Interleukin-2
ターゲットの別称	T-cell growth factor，IL2，Interleukin 2，T Cell Growth Factor，Aldesleukin，IL-2，TCGF，Involved In Regulation Of T-Cell Clonal Expansion，Interleukin-2，Lymphokine
市販薬剤の数	2
治験薬の数	43
研究＆開発段階	Approved

IL-2 製品リスト

属性
Protein (14)Kits (7)
製品ライブラリ
オンライン (19)研究中 (2)
種
Human (13)Mouse (5)Cynomolgus (2)Rat (1)
タグ
Fc Tag & Avi Tag (1)His Tag (4)Fc Tag (1)- (7)Tag Free (5)His Tag & Avi Tag (3)
マーカー
Biotin-labeled (4)Unconjugated (10)- (7)

製品番号	種	発現システム	製品説明
HOT CRS-B008	Human	-	Human IL-2 ELISA Kit
HOT GMP-L02H14	Human	E. coli	GMP Human IL-2 Protein
HOT GMP-L02H14F002	Human	E. coli	GMP Human IL-2 Protein (Liquid)
HOT IL2-H5215	Human	HEK293	Human IL-2 Protein, Tag Free (MALS verified)
CRS-A003	Human	-	resDetect™ Human Interleukin-2 (IL-2) ELISA Kit (Residue Testing)
FCSh-001	Human	-	Human IL-2 Detection Kit (Flow Cytometry Bead Assay)
FRT-C03	Human	-	Human IL-2 Detection Kit (TR-FRET)
GMP-L02H14GB01	Human	E. coli	CytoPak GMP Human IL-2 Protein
IL2-H5113GB02	Human	E. coli	CytoPak Human IL-2 Protein, premium grade
IL2-H5269	Human	HEK293	Human IL-2 Protein, Fc Tag (MALS verified)

総数量21

IL-2バックグランド

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

IL-2分子の別称

IL2,TCGF,lymphokine,Interleukin 2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Darleukin/fibromun	L19-IL-2/ L19-TNF-α	Phase 3 Clinical	Philogen Spa	Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Melanoma; Sarcoma, Kaposi	詳細
Bifikafusp alfa	L19-IL-2	Phase 3 Clinical	Philogen Spa	Adenomatous Polyposis Coli; Carcinoma, Basal Cell; Carcinoma, Non-Small-Cell Lung; Melanoma; Pancreatic Neoplasms; Solid tumours	詳細
IBI-363	IBI-363	Phase 3 Clinical		Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Lymphoma; Melanoma; Mucosal Melanoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms	詳細
EQ-101	EQ101; EQ-101; BNZ132-1-40; BNZ-1; BNZ132-1; BNZ-01	Phase 2 Clinical	Bioniz Therapeutics Inc	Alopecia; Alopecia Areata; Leukemia, Large Granular Lymphocytic; Lymphoma, T-Cell, Cutaneous	詳細
umitrelimorgene autodencel	ITI-1000	Phase 2 Clinical	Immunomic Therapeutics Inc	Glioblastoma	詳細
S-95007	S-95007	Phase 2 Clinical	Laboratoires Servier	Immune System Diseases; Inflammation	詳細
SIM-0278	ALM-223; SIM0278	Phase 2 Clinical	Simcere Pharmaceutical Group Ltd	Autoimmune Diseases; Dermatitis, Atopic; Lupus Erythematosus, Systemic; Lupus Nephritis	詳細
Imneskibart	BD-8; AU-007; BDG-8	Phase 2 Clinical	Biolojic Design Inc	Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Skin Melanoma; Solid tumours	詳細
XTX-202	XTX-202	Phase 2 Clinical	Xilio Development Inc, Xilio Therapeutics Inc	Carcinoma, Renal Cell; Melanoma; Solid tumours	詳細
STK-012	STK-012	Phase 2 Clinical	Synthekine Inc	Carcinoma, Non-Small-Cell Lung; Solid tumours	詳細
EGL-001	EGL-001	Phase 2 Clinical	Egle Therapeutics	Neoplasms; Solid tumours	詳細
STI-7349	STI-7349; ILKN421H	Phase 2 Clinical	The Fourth Affiliated Hospital, Zhejiang University School Of Medcine	Carcinoma, Non-Small-Cell Lung; Solid tumours	詳細
LAT-010	LAT010; LAT-010	Phase 2 Clinical	Latticon Antibody Therapeutics Inc	Neoplasm Metastasis; Solid tumours	詳細
COYA-302	COYA 302; COYA-302; COYA302	Phase 2 Clinical	Coya Therapeutics Inc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Parkinson Disease	詳細
KB-707	KB707; KB-707	Phase 2 Clinical	Krystal Biotech Inc	Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Melanoma; Neoplasms; Skin Melanoma; Solid tumours	詳細
REGN-10597	REGN-10597	Phase 2 Clinical	Regeneron Pharmaceuticals Inc	Carcinoma, Renal Cell; Melanoma; Neoplasms; Solid tumours	詳細
SAR-444336	SAR-444336; THOR-809	Phase 2 Clinical	Sanofi	Colitis, Microscopic; Inflammation	詳細
COYA-301	COYA-301	Phase 2 Clinical	Coya Therapeutics Inc	Alzheimer Disease	詳細
Saltikva	MDB401B	Phase 2 Clinical	Salspera LLC, Sunshine Lake Pharma	Pancreatic Neoplasms	詳細
Igrelimogene litadenorepvec	PM-1016; PM1016; TILT-123	Phase 2 Clinical	Tilt Biotherapeutics Ltd	Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Lung Neoplasms; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
LMBP2-specific TCR-T cell therapy (TCRCure Biopharma)		Phase 2 Clinical	Tcrcure Biopharma Ltd	Nasopharyngeal Carcinoma	詳細
Interleukin-2 gene therapy (St Jude Children's Research Hospital)		Phase 1 Clinical	National Cancer Institute, St. Jude Children'S Research Hospital	Neuroblastoma	詳細
T20K	T-20K	Phase 1 Clinical	Cyxone	Multiple Sclerosis	詳細
ODC-IL2	ODC-IL-2; ODC-IL2; ODC-1L2	Phase 1 Clinical	Trutino Biosciences Inc	Neoplasms; Solid tumours	詳細
Etakafusp alfa	AB-248	Phase 1 Clinical	Asher Biotherapeutics Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Melanoma; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	詳細
ASP-1012	VET2-L2; ASP-1012; ASP1012	Phase 1 Clinical	KaliVir Immunotherapeutics Inc	Solid tumours	詳細
TEV-278	TEV-278; TEV-‘278	Phase 1 Clinical	Teva Pharmaceutical Industries Ltd	Neoplasms	詳細
HM-16390	HM-16390; HM16390	Phase 1 Clinical	Hanmi Pharmaceutical Co Ltd	Solid tumours	詳細
IL2 CD25 fusion protein (Bristol-Myers Squibb)		Phase 1 Clinical	University Of Miami	Autoimmune Diseases	詳細
EGL-003	EGL-003	Phase 1 Clinical	Egle Therapeutics	Autoimmune Diseases; Dermatitis, Atopic; Neoplasms	詳細
KYS-202003-A	KYS-202003-A; KYS202003A	Phase 1 Clinical	Jiangsu Kanion Pharmaceutical Co Ltd	Solid tumours	詳細
M5A-IL2 Immunocytokine	M5A-ICK	Phase 1 Clinical	City Of Hope National Medical Center, National Cancer Institute	Breast Neoplasms; Colorectal Neoplasms	詳細
DF-6215	DF6215; DF-6215	Phase 1 Clinical	Dragonfly Therapeutics Llc	Solid tumours	詳細
Dodekin		Phase 1 Clinical	Philogen Spa	Solid tumours	詳細
TEV-56278	TEV-56278	Phase 1 Clinical	Teva Pharmaceutical Industries Ltd	Melanoma; Neoplasms; Solid tumours	詳細
AttIL2-T cell therapy		Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Osteosarcoma; Sarcoma; Soft Tissue Neoplasms	詳細
Autologous tumor-infiltrating lymphocyte cells therapy (Hervor Therapeutics)	HV-101; HV101	Phase 1 Clinical	Hangzhou Houwu Biomedical Technology Co Ltd, Hervor Therapeutics, Tcrcure Biopharma Ltd	Solid tumours	詳細
KY-0118	KY-0118; KY0118	Phase 1 Clinical	Novatim Immune Therapeutics (Zhejiang) Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Melanoma; Neoplasms; Pancreatic Neoplasms; Solid tumours	詳細
VIS171	VIS-171; VIS171	Phase 1 Clinical	Visterra Inc	Alopecia Areata; Autoimmune Diseases; Glomerulosclerosis, Focal Segmental; Lupus Erythematosus, Systemic	詳細
MK-1484	MK-1484; SP-482	Phase 1 Clinical	Merck & Co Inc, Sutro Biopharma Inc	Solid tumours	詳細
CUG-252	CUG-252	Phase 1 Clinical	Cugene Inc	Autoimmune Diseases; Lupus Erythematosus, Systemic	詳細
RS-2102	RS2102	Phase 1 Clinical	Reistone Biopharma Co Ltd	Dermatitis, Atopic	詳細
BNT-153	BNT-153	Phase 1 Clinical	Biontech Se	Solid tumours	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Propagermanium	SK-818; SK-818C	Approved	Sanwa Kagaku Kenkyusho Co Ltd	Serocion	Japan	Hepatitis B	Sanwa Kagaku Kenkyusho Co Ltd	1994-01-01	Hepatitis B	詳細
Thalidomide	NSC-66847; NSC-527179; K-17; FPF-300; FPF300	Approved	Celgene Corp	Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled	Mainland China	Leprosy, Lepromatous; Multiple Myeloma	Changzhou Pharmaceutical Factory	1982-01-01	Acquired Immunodeficiency Syndrome; Adenocarcinoma, Clear Cell; Adenoma, Islet Cell; Amyotrophic Lateral Sclerosis; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Anemia, Sideroblastic; Angiodysplasia; Appendiceal Neoplasms; Arachnoiditis; Arteriovenous Malformations; Axial Spondyloarthritis; beta-Thalassemia; Burning Mouth Syndrome; Carcinoid Tumor; Carcinoma, Adenosquamous; Carcinoma, Hepatocellular; Cholangitis, Sclerosing; Colorectal Neoplasms; Cough; Endometrial Neoplasms; Endometriosis; Epilepsy; Erythema Nodosum; Gastric Antral Vascular Ectasia; Gastrointestinal Hemorrhage; Genetic Diseases, Inborn; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Hemoglobinopathies; HIV Infections; HIV Wasting Syndrome; Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypertension, Portal; Idiopathic Pulmonary Fibrosis; Kidney Neoplasms; Leiomyosarcoma; Leprosy, Lepromatous; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Chronic; Liver Neoplasms; Lung Neoplasms	詳細

レビュー

JC2024-12-11
2評価
GMP Human IL-2 Protein
This product was ordered for the purpose of culturing immune cells; these cells were in turn used in downstream experiments to assess the efficacy and toxicity of ADCs. This product was delivered punctually and the labels were very clear. There is more than sufficient volume, and it worked seamlessly compared to products tried in the past. It is highly recommended for other users who work with immune cells.
K***s2023-05-18
0評価
Cynomolgus IL-2 Protein, His Tag
My lab utilized this antibody as an analyte to prove/disprove binding capability to one of our proprietary antibodies. In addition to antibody screening, we also used it as a positive control to compare efficacy of in house IL2. We used it on Octet, which works with BLI technology to determine binding affinities. We appreciate the quick shipping and delivery of this product as our assays needed to be completed within a specific timeline.