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IL-2 R alpha

IL-2 R alpha 詳細

英語名	Interleukin-2 receptor alpha chain	市販薬剤の数	3
治験薬の数	16	ターゲットの別称	TAC antigen，p55，IL2-RA，Interleukin-2 receptor subunit alpha，IL-2-RA，IL-2R subunit alpha，IL2RA，Interleukin 2 Receptor Subunit Alpha，Interleukin 2 Receptor， Alpha，IL-2 Receptor Subunit Alpha，Insulin-Dependent Diabetes Mellitus 10，CD25 Antigen，IDDM10，IMD41，TCGFR，CD25，Interleukin-2 Receptor alpha Subunit，IL-2R alpha
研究＆開発段階	Approved

英語名	Interleukin-2 receptor alpha chain
ターゲットの別称	TAC antigen，p55，IL2-RA，Interleukin-2 receptor subunit alpha，IL-2-RA，IL-2R subunit alpha，IL2RA，Interleukin 2 Receptor Subunit Alpha，Interleukin 2 Receptor， Alpha，IL-2 Receptor Subunit Alpha，Insulin-Dependent Diabetes Mellitus 10，CD25 Antigen，IDDM10，IMD41，TCGFR，CD25，Interleukin-2 Receptor alpha Subunit，IL-2R alpha
市販薬剤の数	3
治験薬の数	16
研究＆開発段階	Approved

IL-2 R alpha 製品リスト

属性
Protein (11)
製品ライブラリ
オンライン (11)
種
Human (4)Mouse (2)Canine (1)Cynomolgus (2)Rhesus macaque (1)Rat (1)
タグ
Fc Tag (1)His Tag (6)His Tag & Avi Tag (3)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (7)Biotin-labeled (4)

製品番号	種	発現システム	製品説明
HOT ILA-H5251	Human	HEK293	Human IL-2 R alpha / CD25 Protein, Fc Tag, low Endotoxin (MALS verified)
HOT ILA-H52H9	Human	HEK293	Human IL-2 R alpha / CD25 Protein, His Tag, low endotoxin (MALS verified)
HOT ILA-H82E6	Human	HEK293	Biotinylated Human IL-2 R alpha / CD25 Protein, His,Avitag™, premium grade
HOT ILA-M52H9	Mouse	HEK293	Mouse IL-2 R alpha / CD25 Protein, His Tag (MALS verified)
HOT ILA-C52H8	Cynomolgus	HEK293	Cynomolgus IL-2 R alpha / CD25 Protein, His Tag, low endotoxin (MALS verified)
ILA-H82F9	Human	HEK293	Biotinylated Human IL-2 R alpha / CD25 Protein, Fc,Avitag™ (MALS verified)
ILA-M82E9	Mouse	HEK293	Biotinylated Mouse IL-2 R alpha / CD25 Protein, His,Avitag™ (MALS verified)
ILA-C52H4	Canine	HEK293	Canine IL-2 R alpha / CD25 Protein, His Tag
ILA-C82E4	Cynomolgus	HEK293	Biotinylated Cynomolgus IL-2 R alpha / CD25 Protein, His,Avitag™ (MALS verified)
ILA-R52H3	Rhesus macaque	HEK293	Rhesus macaque IL-2 R alpha / CD25 Protein, His Tag (MALS verified)

総数量11

IL-2 R alpha分子の別称

IL2RA,CD25,p55,IL2-RA,IL-2-RA

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
CD25 mAb - 01	PCC	Monoclonal	Humanized Mouse	Solid Tumor	Solid tumor

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Basiliximab biobetter (Mabtech/Sorrento)	STI-003	Phase 3 Clinical	Taizhou Maibo Taike Biotechnology Co Ltd	Autoimmune Diseases	詳細
LMB-2	LMB-2; LMB-2a	Phase 2 Clinical	National Cancer Institute	Leukemia; Leukemia, Hairy Cell; Leukemia, T-Cell; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Skin Melanoma; Skin Neoplasms	詳細
Nemvaleukin alfa	RDB-1419; RDB-1450; ALKS-4230	Phase 2 Clinical	Alkermes Plc	Fallopian Tube Neoplasms; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
Camidanlumab tesirine	ADCT-301	Phase 2 Clinical	Adc Therapeutics Sa, Genmab A/S	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Hodgkin Disease; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Melanoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	詳細
90Y-HAT (NCI)		Phase 2 Clinical	National Cancer Institute	Hodgkin Disease; Lymphoma, Non-Hodgkin	詳細
Humanized Anti-CD25 Antibody(Institute of Hematology & Blood Diseases Hospital)		Phase 2 Clinical	Institute Of Hematology & Blood Diseases Hospital	Graft vs Host Disease	詳細
90Y Basiliximab		Phase 2 Clinical	City Of Hope National Medical Center	Hodgkin Disease; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
PT-101	PT-101; MK-6194; PT101	Phase 1 Clinical	Pandion Therapeutics	Colitis, Ulcerative; Dermatitis, Atopic; Lupus Erythematosus, Systemic; Vitiligo	詳細
Anti-interleukin-2 receptor monoclonal antibody Mikbeta1	HuMikβ1-1	Phase 1 Clinical	F. Hoffmann-La Roche Ltd, National Institutes Of Health	Celiac Disease; Leukemia; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphoid; Paraparesis, Tropical Spastic	詳細
BA-1106	TS-1904; BA-1106; RR-102	Phase 1 Clinical	Shandong Boan Biotechnology Co Ltd	Solid tumours	詳細
XmAb-564	XmAb-564; XmAb564; XmAb-27564	Phase 1 Clinical	Xencor Inc	Autoimmune Diseases; Dermatitis, Atopic; Psoriasis	詳細
PF-08046032	PF-08046032	Phase 1 Clinical	Pfizer Inc	Carcinoma, Non-Small-Cell Lung; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Melanoma; Neoplasms; Squamous Cell Carcinoma of Head and Neck	詳細
IL2 CD25 fusion protein (Bristol-Myers Squibb)		Phase 1 Clinical	University Of Miami	Autoimmune Diseases	詳細
9MW-3911	9MW3911; 9MW-3911	Phase 1 Clinical	Nanjing Nuo Aixin Biotechnology Co Ltd	Neoplasms	詳細
In 111-DOTA-Basiliximab		Phase 1 Clinical	City Of Hope National Medical Center	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	詳細
BMS-986326	BMS-986326	Phase 1 Clinical	Bristol-Myers Squibb Company	Dermatitis, Atopic; Lupus Vulgaris	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Daclizumab biosimilar (Shanghai CP Guojian)		Approved	Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd	健尼哌	Mainland China	Rejection of renal transplantation	null	2011-01-12	Rejection of renal transplantation	詳細
Daclizumab	R-35; BIIB-019; RO-247375	Approved	Abbvie Inc, Biogen Inc, F. Hoffmann-La Roche Ltd	Zinbryta, Zenapax	United States	Rejection of organ transplantation	F. Hoffmann-La Roche Ag	1997-12-10	Anemia, Aplastic; Anemia, Diamond-Blackfan; Arthritis, Juvenile; Asthma; Behcet Syndrome; Breast Neoplasms; Carcinoma, Ductal; Colitis, Ulcerative; Diabetes Mellitus, Type 1; Gastrointestinal Diseases; Granulomatosis with Polyangiitis; HIV Infections; HTLV-I Infections; Inflammatory Bowel Diseases; Iritis; Leukemia; Leukemia, T-Cell; Lymphoma; Melanoma; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Psoriasis; Radiation Injuries; Red-Cell Aplasia, Pure; Rejection in heart transplantation; Rejection of organ transplantation; Retinal Diseases; Thrombocytopenia; Uveitis; Uveitis, Anterior	詳細
Basiliximab	CHT-25; chRFT5; CHI-621; SDZ-CHI-621	Approved	Novartis Pharma Ag	舒莱, Simulect	United States	Rejection of organ transplantation	Novartis Pharma Ag	1998-05-12	Anemia, Aplastic; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Cytokine Release Syndrome; Emphysema; Hemoglobinuria, Paroxysmal; Hodgkin Disease; Keratoplasty rejection; Kidney Failure, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Pulmonary Disease, Chronic Obstructive; Rejection of renal transplantation; Rejection of organ transplantation; Uveitis	詳細

レビュー

E***n2023-04-08
1評価
Human IL-2 R alpha / CD25 Protein, His Tag, low endotoxin (MALS verified)
Yeast cells expressing and displaying different IL2 variants were incubated 1h in the presence of CD25 protein with His tag (Human Il-2 R alpha Acrobiosystems #ILA-H52H9) at a final concentration of 4µg/ml. Next, cells were washed and incubated with a mouse Anti-His-PE. The yeast cells were washed and were analyzed using FACS. We observed detectable amounts of fluorescence bound to yeast cells displaying specific IL2 variants confirming that CD25 could bind to certain constructs and providing evidence that certain IL2 variants were correctly folded.
1***22022-08-03
0評価
Mouse IL-2 R alpha / CD25 Protein, His Tag (MALS verified)
I purchased the company’s mouse-derived CD25 protein for the evaluation of CD25 antibody affinity. It achieved a high sensitivity detection with a small amount! Very satisfied, will come back to purchase more if needed!