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IL-2 R beta

IL-2 R beta 詳細

英語名	Interleukin-2 receptor beta chain	市販薬剤の数	0
治験薬の数	15	ターゲットの別称	IL2RB，IMD63，IL-2RB，p75，CD122，Interleukin 2 Receptor Subunit Beta，Interleukin-15 Receptor Subunit Beta，Interleukin 15 Receptor， Beta，Interleukin 2 Receptor， Beta，IL-2R Subunit Beta，CD122 Antigen，P70-75，IL15RB，High Affinity IL-2 Receptor Beta Subunit，Interleukin-2 Receptor beta Subunit，Interleukin-2 receptor subunit beta，IL-2 receptor subunit beta，High affinity IL-2 receptor subunit beta
研究＆開発段階	Phase 3 Clinical

英語名	Interleukin-2 receptor beta chain
ターゲットの別称	IL2RB，IMD63，IL-2RB，p75，CD122，Interleukin 2 Receptor Subunit Beta，Interleukin-15 Receptor Subunit Beta，Interleukin 15 Receptor， Beta，Interleukin 2 Receptor， Beta，IL-2R Subunit Beta，CD122 Antigen，P70-75，IL15RB，High Affinity IL-2 Receptor Beta Subunit，Interleukin-2 Receptor beta Subunit，Interleukin-2 receptor subunit beta，IL-2 receptor subunit beta，High affinity IL-2 receptor subunit beta
市販薬剤の数	0
治験薬の数	15
研究＆開発段階	Phase 3 Clinical

IL-2 R beta 製品リスト

属性
Protein (9)
製品ライブラリ
オンライン (9)
種
Human (3)Mouse (2)Canine (1)Cynomolgus (3)
タグ
His Tag (4)Fc Tag (3)His Tag & Avi Tag (2)
マーカー
Unconjugated (7)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT CD2-H5221	Human	HEK293	Human IL-2 R beta / CD122 Protein, His Tag, low endotoxin (HPLC & SPR verified)
HOT ILB-H82E3	Human	HEK293	Biotinylated Human IL-2 R beta / CD122 Protein, His,Avitag™
HOT ILA-M52H5	Mouse	HEK293	Mouse IL-2 R beta Protein, His Tag, low endotoxin
HOT ILB-C52H9	Cynomolgus	HEK293	Cynomolgus IL-2 R beta / CD122 Protein, His Tag (MALS verified)
ILB-H5253	Human	HEK293	Human IL-2 R beta / CD122 Protein, Fc Tag (MALS & SPR verified)
ILB-M5253	Mouse	HEK293	Mouse IL-2 R beta / CD122 Protein, Fc Tag
ILA-C5253	Cynomolgus	HEK293	Cynomolgus IL-2 R beta Protein, Fc Tag
ILA-C52H5	Canine	HEK293	Canine IL-2 R beta Protein, His Tag
ILA-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus IL-2 R beta Protein, His,Avitag™ (MALS verified)

総数量9

IL-2 R betaバックグランド

Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

IL-2 R beta分子の別称

IL2RB,RP5-1170K4.6,CD122,P70-75

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Bempegaldesleukin	BMS-986321; ONO-7911; NKTR-214	Phase 3 Clinical	Nektar Therapeutics	Brain Neoplasms; Carcinoma, Renal Cell; Coronavirus Disease 2019 (COVID-19); Ependymoma; Glioma; Head and Neck Neoplasms; Leukemia; Lymphoma; Medulloblastoma; Melanoma; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Prostatic Neoplasms, Castration-Resistant; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms	詳細
AWT-020	AWT020; AWT-020; JS213; JS-213	Phase 2 Clinical	Anwita Biosciences Inc	Autoimmune Diseases of the Nervous System; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Neoplasms; Solid tumours	詳細
GI-101	SIM-323; SIM323; SIM0323; GI-101	Phase 2 Clinical	GI Innovation Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Neoplasms; Solid tumours; Uterine Cervical Neoplasms	詳細
MB-501	MB501; MB-501	Phase 2 Clinical	Ascendis Pharma Inc	Neoplasms	詳細
Pegenzileukin	IBI-127; THOR-707; SAR-444245	Phase 2 Clinical	Synthorx Inc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Hodgkin Disease; Intestinal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Melanoma; Mesothelioma; Multiple Myeloma; Neoplasm Metastasis; Oropharyngeal Neoplasms; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	詳細
IPH-6501	IPH-6501; IPH-65	Phase 2 Clinical	Innate Pharma SA	Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms	詳細
LTC-004	LTC004; LTC-004	Phase 2 Clinical	Leto Laboratories Co Ltd	Colorectal Neoplasms; Neoplasms; Pancreatic Neoplasms; Sarcoma; Solid tumours	詳細
FB-102	FB-102; FB102	Phase 2 Clinical	Forte Biosciences Inc	Alopecia Areata; Celiac Disease; Graft vs Host Disease; Malabsorption Syndromes; Vitiligo	詳細
TransCon IL-2 β/γ		Phase 2 Clinical	Ascendis Pharma A/S	Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Ovarian Neoplasms; Solid tumours	詳細
MDNA-11	MDNA-11; MDNA11	Phase 2 Clinical	Medicenna Therapeutics Corp	Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Melanoma; Mesothelioma; Microsatellite Instability; Microsatellite instability-high cancer; Mismatch Repair Deficient Cancer; Ovarian Neoplasms; Peritoneal Neoplasms; Skin Melanoma; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
Simlukafusp alfa	FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP	Phase 1 Clinical	F. Hoffmann-La Roche Ltd	Breast Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Head and Neck Neoplasms; Melanoma; Solid tumours; Uterine Cervical Neoplasms	詳細
BJ-001(Boji Biomedical Technology)	BJ-001	Phase 1 Clinical	Boji Biomedical Technology (Hangzhou) Co Ltd	Communicable Diseases; Neoplasm Metastasis; Solid tumours	詳細
STK-009	STK-009	Phase 1 Clinical	Synthekine Inc	Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Scleroderma, Systemic	詳細
NL-201 (Neoleukin Therapeutics)	NL-201	Phase 1 Clinical	Neoleukin Therapeutics Inc	Solid tumours	詳細
Recombinant human interleukin 15(Beijing Kawin)		Phase 1 Clinical	Beijing Kawin Technology Share-Holding Co Ltd	Solid tumours	詳細

レビュー

V***n2025-02-11
1評価
Human IL-2 R beta / CD122 Protein, His Tag, low endotoxin (HPLC & SPR verified)
I bought this Human recombinant IL-2 R β / CD122 protein to test some anti-CD122 antibodies using ELISA assays where I coat the plate with the CD122 protein. I observed the expected affinity (Kd) results for my antibody (0.3 µg/mL), and I also observed the same results whether I used the CD122 protein freshly reconstituted or freeze-thawed once, showing that this is a really robust purified protein! Lastly, I compared coating my ELISA plates with varying concentrations of CD122 protein (0.25 - 8 µg/mL), finding that I could coat my plates with very little proteins and still observed consistent affinity measurements. This product is a really robust! I will definitely be buying products from Acro Biosystems in the future.