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IL-31

IL-31 詳細

英語名	Interleukin-31	市販薬剤の数	0
治験薬の数	5	ターゲットの別称	Interleukin 31，IL-31
研究＆開発段階	Phase 2 Clinical

英語名	Interleukin-31
ターゲットの別称	Interleukin 31，IL-31
市販薬剤の数	0
治験薬の数	5
研究＆開発段階	Phase 2 Clinical

IL-31 製品リスト

属性
Protein (8)Kits (1)
製品ライブラリ
オンライン (9)
種
Human (4)Cynomolgus (3)Mouse (2)
タグ
His Tag (4)His Tag & Avi Tag (3)Tag Free (1)- (1)
マーカー
Unconjugated (5)Biotin-labeled (3)- (1)

製品番号	種	発現システム	製品説明
HOT IL1-H5219	Human	HEK293	Human IL-31 Protein, premium grade (Mass Spec verified)
HOT IL1-H5247	Human	HEK293	Human IL-31 Protein, His Tag, low Endotoxin (MALS verified)
HOT IL1-C5245	Cynomolgus	HEK293	Cynomolgus IL-31 Protein, His Tag, low endotoxin
CEA-C243	Human	-	Human IL-31 ELISA Kit
IL1-H82E6	Human	HEK293	Biotinylated Human IL-31 Protein, His,Avitag™ (MALS verified)
IL1-M5244	Mouse	HEK293	Mouse IL-31 Protein, His Tag (HPLC verified)
IL1-M82Q9	Mouse	HEK293	Biotinylated Mouse IL-31 Protein, His,Avitag™ (MALS & BLI verified)
IL1-C52H3	Cynomolgus	HEK293	Cynomolgus IL-31 Protein, His Tag, ultra low endotoxin (MALS verified)
IL1-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus IL-31 Protein, His,Avitag™ (HPLC verified)

総数量9

お問い合わせ

IL-31バックグランド

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

IL-31分子の別称

IL-31,IL31,Interleukin-31

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
JNJ-5939	JNJ-5939; NM-26; NM26-2198; JNJ-95475939	Phase 2 Clinical	Numab Therapeutics Ag	Dermatitis, Atopic; Inflammation	詳細
ATTO-3712	ATTO-3712	Phase 1 Clinical	Attovia Therapeutics Inc	Dermatitis, Atopic; Pruritus	詳細
BBT-001	BBT001; BBT-001	Phase 1 Clinical	Bambusa Therapeutics Inc	Dermatitis, Atopic	詳細
ZL-1503	ZL-1503	Phase 1 Clinical	Zai Lab Ltd	Dermatitis, Atopic	詳細
ATTO-1310	ATTO-1310	Phase 1 Clinical	Attovia Therapeutics Inc	Dermatitis, Atopic; Pruritus	詳細