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IL-5 R alpha

IL-5 R alpha 詳細

英語名	Interleukin-5 receptor subunit alpha	市販薬剤の数	1
治験薬の数	2	ターゲットの別称	Interleukin 5 Receptor， Alpha，Interleukin-5 Receptor Subunit Alpha，HSIL5R3，Interleukin-5 Receptor Alpha Chain，CDw125，Interleukin-5 Receptor alpha Subunit，Interleukin 5 Receptor Type 3，CD125 Antigen，Interleukin 5 Receptor Subunit Alpha，IL-5 Receptor Subunit Alpha，IL-5R-Alpha，IL5R，IL5RA，CD125，IL-5RA，IL-5R Subunit Alpha
研究＆開発段階	Approved

英語名	Interleukin-5 receptor subunit alpha
ターゲットの別称	Interleukin 5 Receptor， Alpha，Interleukin-5 Receptor Subunit Alpha，HSIL5R3，Interleukin-5 Receptor Alpha Chain，CDw125，Interleukin-5 Receptor alpha Subunit，Interleukin 5 Receptor Type 3，CD125 Antigen，Interleukin 5 Receptor Subunit Alpha，IL-5 Receptor Subunit Alpha，IL-5R-Alpha，IL5R，IL5RA，CD125，IL-5RA，IL-5R Subunit Alpha
市販薬剤の数	1
治験薬の数	2
研究＆開発段階	Approved

IL-5 R alpha 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (4)
種
Human (3)Mouse (1)
タグ
His Tag (2)Fc Tag (1)Avi Tag & Fc Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
ILA-H5269	Human	HEK293	Human IL-5 R alpha / CD125 Protein, Fc Tag (MALS verified)
ILA-H52H4	Human	HEK293	Human IL-5 R alpha / CD125 Protein, His Tag, low endotoxin (MALS verified)
ILA-H82F5	Human	HEK293	Biotinylated Human IL-5 R alpha / CD125 Protein, Avitag™,Fc Tag (MALS verified)
ILA-M52H7	Mouse	HEK293	Mouse IL-5 R alpha / CD125 Protein, His Tag (MALS & SPR verified)

総数量4

IL-5 R alphaバックグランド

Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

IL-5 R alpha分子の別称

IL5Ra,CD125

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
IL-5 CAR-T Cell Therapy (Zhejiang University)		Phase 1 Clinical	Zhejiang University	Hematologic Diseases; Neoplasms	詳細
Trabikibart	CSL-311	Phase 1 Clinical	Csl Ltd	Asthma	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Benralizumab	KHK-4563; MEDI-563; BIW-8405; BIW-8405-IL-5R	Approved	Biowa Inc, Medimmune Llc	Fasenra, 凡舒卓	United States	Asthma	Astrazeneca Ab	2017-11-14	Asthma; Asthma, Exercise-Induced; Bronchiectasis; Chronic Urticaria; Dermatitis; Dermatitis, Atopic; Drug Hypersensitivity Syndrome; Eczema; Eosinophilia; Eosinophilic Asthma; Eosinophilic Esophagitis; Eosinophilic gastroenteritis (EG); Eosinophilic Granulomatosis With Polyangiitis; Gastroenteritis; Genetic Diseases, Inborn; Granulomatosis with Polyangiitis; Hematologic Diseases; Hypereosinophilic Syndrome; Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Leukocyte Disorders; Nasal Polyps; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Sinusitis; Skin Diseases; Skin Diseases, Eczematous; Skin Diseases, Genetic	詳細