IL-7 R alpha & TSLP R 詳細
Molecule Name
Interleukin-7 receptor subunit alpha
分子の別称
IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2
Drug Development Progress
治験薬の数8
市販薬剤の数0
研究＆開発段階Phase 2 Clinical
ターゲットの別称
Interleukin-7 receptor subunit alpha，Interleukin 7 Receptor Isoform H5-6，CDw127，IL-7R subunit alpha，IL-7RA，IL-7 receptor subunit alpha，CD127 Antigen，IL-7R-Alpha，Interleukin 7 Receptor Alpha Chain，CD127，IL7RA，ILRA，Interleukin-7 Receptor alpha Subunit
バックグランド
TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.
IL-7 R alpha & TSLP R 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| CYT-107 | CYT-107; CYT-99-007; rhIL-7 | Phase 2 Clinical | Revimmune Inc | Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Catheter-Related Infections; Coronavirus Disease 2019 (COVID-19); Hepatitis B, Chronic; Hepatitis C; HIV Infections; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Lymphopenia; Metastatic breast cancer; Multiple Myeloma; Mycobacterium Infections, Nontuberculous; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Sarcoma, Kaposi; Sepsis; Shock, Septic; Skin Melanoma; T-Lymphocytopenia, Idiopathic CD4-Positive; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms | 詳細 |
| Lusvertikimab | OSE-127; S-95011; Effi-7; OSE-217 | Phase 2 Clinical | Effimune | Colitis, Ulcerative; Sjogren's Syndrome | 詳細 |
| Efineptakin alfa | TJ-107; GX-I7; NT-I7 | Phase 2 Clinical | Gannex Pharma Co Ltd | Astrocytoma; Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Esophageal Neoplasms; Glioblastoma; Glioma; Gliosarcoma; HIV Infections; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Leukoencephalopathy, Progressive Multifocal; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphopenia; Melanoma; Multiple Myeloma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Papillomavirus Infections; Plasmablastic Lymphoma; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Kaposi; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms | 詳細 |
| ASP-9801 | ASP-9801 | Phase 1 Clinical | Astellas Pharma Inc | Neoplasm Metastasis; Neoplasms; Solid tumours | 詳細 |
| PF-06342674 | RN-168; PF-6342674; PF-06342674; ZB-168 | Phase 1 Clinical | Pfizer Inc | Diabetes Mellitus, Type 1; Multiple Sclerosis | 詳細 |
| CD19-IL7Ra CAR-T cells therapy (Chulalongkorn University) | CMD-63; CMD63 | Phase 1 Clinical | Chulalongkorn University | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 詳細 |
| Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) | Phase 1 Clinical | Chulalongkorn University, King Chulalongkorn Memorial Hospital | Brain Neoplasms; Diffuse Intrinsic Pontine Glioma; Neoplasms; Solid tumours | 詳細 | |
| MDK-703 | MDK-703 | Phase 1 Clinical | Medikine Inc | Solid tumours | 詳細 |