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IL-8

IL-8 詳細

英語名	Interleukin-8	市販薬剤の数	1
治験薬の数	6	ターゲットの別称	IL8/NAP1 form VI，T-cell chemotactic factor，GCP/IL-8 protein III，IL8/NAP1 form II，GCP/IL-8 protein II，(Ala-IL-8)77，Emoctakin，IL8/NAP1 form IV，LYNAP，IL8/NAP1 form III，IL8/NAP1 form V，GCP/IL-8 protein I，Neutrophil-Activating Peptide 1，Interleukin 8，GCP-1，MDNCF，NAP-1，IL8，Beta Endothelial Cell-Derived Neutrophil Activating Peptide，Lung Giant Cell Carcinoma-Derived Chemotactic Protein，Lymphocyte Derived Neutrophil Activating Peptide，Alveolar Macrophage Chemotactic Factor I，Tumor Necrosis Factor-Induced Gene 1，Small Inducible Cytokine Subfamily B， Member 8，Beta-Thromboglobulin-Like Protein，GCP1，LECT，LUCT，NAP1，IL-8，Interleukin-8，AMCF-I，SCYB8，Neutrophil-Activating Protein 1，B-ENAP，3-10C，K60，TSG-1，C-X-C Motif Chemokine Ligand 8，Monocyte-Derived Neutrophil Chemotactic Factor，Monocyte-Derived Neutrophil-Activating Peptide，Granulocyte Chemotactic Protein 1，Chemokine (C-X-C Motif) Ligand 8，(Ser-IL-8)72，Neutrophil-activating factor，MDNCF-c，C-X-C motif chemokine 8，Lymphocyte-derived neutrophil-activating factor，Protein 3-10C，IL-8(1-77)，NAF，GCP/IL-8 protein VI，GCP/IL-8 protein IV，IL8/NAP1 form I，MONAP，MDNCF-b，GCP/IL-8 protein V，CXCL8
研究＆開発段階	Approved

英語名	Interleukin-8
ターゲットの別称	IL8/NAP1 form VI，T-cell chemotactic factor，GCP/IL-8 protein III，IL8/NAP1 form II，GCP/IL-8 protein II，(Ala-IL-8)77，Emoctakin，IL8/NAP1 form IV，LYNAP，IL8/NAP1 form III，IL8/NAP1 form V，GCP/IL-8 protein I，Neutrophil-Activating Peptide 1，Interleukin 8，GCP-1，MDNCF，NAP-1，IL8，Beta Endothelial Cell-Derived Neutrophil Activating Peptide，Lung Giant Cell Carcinoma-Derived Chemotactic Protein，Lymphocyte Derived Neutrophil Activating Peptide，Alveolar Macrophage Chemotactic Factor I，Tumor Necrosis Factor-Induced Gene 1，Small Inducible Cytokine Subfamily B， Member 8，Beta-Thromboglobulin-Like Protein，GCP1，LECT，LUCT，NAP1，IL-8，Interleukin-8，AMCF-I，SCYB8，Neutrophil-Activating Protein 1，B-ENAP，3-10C，K60，TSG-1，C-X-C Motif Chemokine Ligand 8，Monocyte-Derived Neutrophil Chemotactic Factor，Monocyte-Derived Neutrophil-Activating Peptide，Granulocyte Chemotactic Protein 1，Chemokine (C-X-C Motif) Ligand 8，(Ser-IL-8)72，Neutrophil-activating factor，MDNCF-c，C-X-C motif chemokine 8，Lymphocyte-derived neutrophil-activating factor，Protein 3-10C，IL-8(1-77)，NAF，GCP/IL-8 protein VI，GCP/IL-8 protein IV，IL8/NAP1 form I，MONAP，MDNCF-b，GCP/IL-8 protein V，CXCL8
市販薬剤の数	1
治験薬の数	6
研究＆開発段階	Approved

IL-8 製品リスト

属性
Protein (5)Kits (3)
製品ライブラリ
オンライン (7)研究中 (1)
種
Human (7)Rhesus macaque (1)
タグ
His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)- (3)Tag Free (1)
マーカー
Unconjugated (4)Biotin-labeled (1)- (3)

製品番号	種	発現システム	製品説明
HOT CRS-B004	Human	-	Human IL-8 ELISA Kit
HOT IL8-H5217	Human	HEK293	Human IL-8 / CXCL8 Protein, premium grade
HOT IL8-H52H3	Human	HEK293	Human IL-8 / CXCL8 Protein, His Tag
HOT IL8-H82H3	Human	HEK293	Biotinylated Human IL-8 protein, His,Avitag™
HOT IL8-C52H4	Rhesus macaque	HEK293	Rhesus macaque IL-8 / CXCL8 Protein, His Tag (MALS verified)
CEA-C004	Human	-	Human IL-8 ELISA Kit, PRO
FCSh-015	Human	-	Human IL-8 Detection Kit (Flow Cytometry Bead Assay)
IL8-H5258	Human	HEK293	Human IL-8 / CXCL8 Protein, Fc Tag

総数量8

IL-8バックグランド

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

IL-8分子の別称

CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Ensereptide	PXL-01	Phase 3 Clinical	Promore Pharma	Cicatrix; Post-surgical adhesions; Tissue Adhesions	詳細
Cinainu		Phase 3 Clinical	Legacy Healthcare (Switzerland) Sa	Alopecia Areata	詳細
Sodium Hypochlorite		Phase 3 Clinical		Cystic Fibrosis; Dental Pulp Necrosis; Fibrosis; Infections; Pain; Pain, Postoperative; Pulpitis	詳細
Adakitug	BMS-986253; MDX-018	Phase 2 Clinical	Bristol-Myers Squibb Company, Genmab A/S, Medarex Inc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Coronavirus Disease 2019 (COVID-19); Hematologic Neoplasms; Melanoma; Myelodysplastic Syndromes; Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
AMY-109	AMY-109; AMY109	Phase 2 Clinical	Chugai Pharmaceutical Co Ltd	Endometriosis; Solid tumours	詳細
AC-701	AC-701	Phase 2 Clinical	Twi Pharmaceuticals Inc	Exanthema; Rosacea	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Mouse monoclonal antibody against human interleukin-8 cream		Approved	Dalian Asia Space Pharmaceutical Co Ltd, Dongguan Hongyuan Yishi Biotechnology Pharmaceutical Co Ltd	恩博克	Mainland China	Eczema; Psoriasis	Dalian Asia Space Pharmaceutical Co Ltd	2001-04-10	Eczema; Psoriasis	詳細