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IL23A & IL12B
IL23A & IL12B 詳細
| 英語名 | Interleukin-12 subunit beta | 市販薬剤の数 | 8 |
| 治験薬の数 | 2 | ターゲットの別称 | IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2 |
| 研究＆開発段階 | Approved | ||
| 英語名 | Interleukin-12 subunit beta |
| ターゲットの別称 | IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2 |
| 市販薬剤の数 | 8 |
| 治験薬の数 | 2 |
| 研究＆開発段階 | Approved |
IL23A & IL12B 製品リスト
- 属性
Protein (16)
- 製品ライブラリ
オンライン (16)
- 種
Human (3)Human & Mouse (1)Mouse (2)Cynomolgus & Mouse (1)Human & Rat (2)Cynomolgus (2)Rat (1)Rabbit (1)Human | Alpaca (1)Golden Hamster (1)Guinea pig (1)
- タグ
His Tag (12)His Tag & Avi Tag (3)Tag Free (1)
- マーカー
Unconjugated (13)Biotin-labeled (3)
総数量16
- 1
- 2
IL23A & IL12Bバックグランド
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
IL23A & IL12B分子の別称
IL-23 alpha & IL-12 beta
治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| RO-7837195 | RO-7837195; RO7837195 | Phase 2 Clinical | Genentech Inc | Colitis, Ulcerative | 詳細 |
| PF-07261271 | RG-6730; PF-07261271 | Phase 2 Clinical | Pfizer Inc | Inflammatory Bowel Diseases | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Ustekinumab biosimilar (Bio-Thera) | BAT-2206 | Approved | Bio-Thera Solutions Ltd | STARJEMZA, Usymro | United States | Plaque psoriasis; Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic | Bio-Thera Solutions Ltd | 2025-05-22 | Arthritis, Psoriatic; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis | 詳細 |
| Ustekinumab | C-340; CNTO-1275 | Approved | Johnson & Johnson Innovative Medicine | Stelara, 喜达诺 | United States | Plaque psoriasis | Janssen Biotech Inc | 2009-09-25 | Arthritis, Juvenile; Arthritis, Psoriatic; Colitis, Ulcerative; Common Variable Immunodeficiency; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Diabetes Mellitus, Type 1; Hidradenitis Suppurativa; Ichthyosis; Inflammatory Bowel Diseases; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Multiple Sclerosis; Palmoplantar pustulosis; Pediatric Crohn's disease; Plaque psoriasis; Polymyositis; Pouchitis; Psoriasis; Sjogren's Syndrome; Spondylitis, Ankylosing; Takayasu Arteritis; Type I Leukocyte Adhesion Defect; Uveitis | 詳細 |
| Ebdarokimab | AK-101; AK101 | Approved | 爱达罗 | Mainland China | Plaque psoriasis | Zhongshan Akeso Biopharma Co Ltd | 2025-04-15 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis | 詳細 | |
| Ustekinumab Biosimilar(Celltrion) | CT-P43 | Approved | Celltrion Inc | Steqeyma, Steqeyma IV, Qoyvolma | Canada | Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis | Celltrion Inc | 2024-08-01 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis | 詳細 |
| Ustekinumab biosimilar (Biocon) | Bmab 1200 | Approved | Biocon Biologics Ltd | Yesintek | United States | Colitis, Ulcerative; Crohn Disease; Arthritis, Psoriatic | Biocon Biologics Inc | 2024-11-29 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis | 詳細 |
| Ustekinumab biosimilar (Alvotech) | AVT04; AVT-04 | Approved | Alvotech hf | Jamteki, Uzpruvo, SELARSDI™, JamtekiTM, Ustekinumab BS (F) | Japan | Arthritis, Psoriatic; Psoriasis | Fuji Pharma Co Ltd | 2023-09-25 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis | 詳細 |
| Ustekinumab biosimilar (Samsung Bioepis) | SB-17; SB17 | Approved | Samsung Bioepis Co Ltd | Pyzchiva, Eksunbi | EU | Crohn Disease; Colitis, Ulcerative | Samsung Bioepis Nl Bv | 2024-04-19 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Gastrointestinal Diseases; Inflammation; Plaque psoriasis; Psoriasis; Rheumatic Diseases; Skin Diseases | 詳細 |
| Ustekinumab biosimilar (Amgen) | ABP-654; AMG-654 | Approved | Amgen Inc | Wezlana, WEZLANA, wezenla, WEZENLA | United States | Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis | Amgen Inc | 2023-10-31 | Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis | 詳細 |
- 詳細
- 製品リスト
- 市販薬剤に関する情報
- 治験薬に関する情報
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