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ILDR2

ILDR2 詳細

英語名	Immunoglobulin-like domain-containing receptor 2	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
研究＆開発段階	Phase 1 Clinical

英語名	Immunoglobulin-like domain-containing receptor 2
ターゲットの別称	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 1 Clinical

ILDR2 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
Fc Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
IL2-H5259	Human	HEK293	Human ILDR2 Protein, Fc Tag

総数量1

ILDR2バックグランド

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.