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ILDR2

ILDR2 詳細

英語名Immunoglobulin-like domain-containing receptor 2市販薬剤の数0
治験薬の数1ターゲットの別称Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
研究＆開発段階Phase 1 Clinical
英語名Immunoglobulin-like domain-containing receptor 2
ターゲットの別称Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
市販薬剤の数0
治験薬の数1
研究＆開発段階Phase 1 Clinical

ILDR2 製品リスト

  • 属性

    Protein (1)

  • 製品ライブラリ

    オンライン (1)

  • 種

    Human (1)

  • タグ

    Fc Tag (1)

  • マーカー

    Unconjugated (1)

製品番号種発現システム製品説明タンパク質の構造純度特性
IL2-H5259
Human
HEK293
Human ILDR2 Protein, Fc Tag
総数量1
  • 1
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ILDR2バックグランド

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

ILDR2分子の別称

ILDR2,C1orf32

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
BapotulimabBAY-1905254Phase 1 ClinicalCompugen LtdSolid tumours; Squamous Cell Carcinoma of Head and Neck
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