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Integrin alpha D beta 2

Integrin alpha D beta 2 詳細

英語名	Integrin alpha-4	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4
研究＆開発段階	Phase 2 Clinical

英語名	Integrin alpha-4
ターゲットの別称	CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 2 Clinical

Integrin alpha D beta 2 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
IT2-H53W6	Human	CHO	Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free

総数量1

Integrin alpha D beta 2バックグランド

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.

Integrin alpha D beta 2分子の別称

Integrin alpha D beta 2,ITGAD & ITGB2

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Avicursen	TV-1102; ATL/TV-1102; ATL-1102; ISIS-107248	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Multiple Sclerosis; Muscular Dystrophy, Duchenne	詳細
BIIB-107 (Biogen)	BIIB-107	Phase 1 Clinical	Biogen Inc	Multiple Sclerosis	詳細
ELND-004	ELND-004	Phase 1 Clinical	Perrigo Company Plc	Autoimmune Diseases	詳細