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Integrin alpha V beta 6

Integrin alpha V beta 6 詳細

英語名	Integrin alpha-V/beta-6	市販薬剤の数	0
治験薬の数	6	ターゲットの別称
研究＆開発段階	Phase 2 Clinical

英語名	Integrin alpha-V/beta-6
ターゲットの別称
市販薬剤の数	0
治験薬の数	6
研究＆開発段階	Phase 2 Clinical

Integrin alpha V beta 6 製品リスト

属性
Protein (8)Cell (2)Kits (1)
製品ライブラリ
オンライン (11)
種
Human (5)Mouse (2)Cynomolgus (2)Rat (1)Mouse & Human (1)
タグ
His Tag (5)His Tag & Avi Tag (3)- (3)
マーカー
Unconjugated (5)Biotin-labeled (3)- (3)

製品番号	種	発現システム	製品説明
HOT IT6-H52E1	Human	HEK293	Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
HOT IT6-H82E4	Human	HEK293	Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
HOT IT6-M52W9	Mouse	HEK293	Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)
HOT IT6-C52W9	Cynomolgus	HEK293	Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
CCHO-ATP254	Human	CHO	CHO/Human Integrin alpha V beta 6 Stable Cell Line
CHEK-ATP125	Human	HEK293	HEK293/Human Integrin alpha V beta 6 Stable Cell Line
AI Compatible FRT-P020	Human	-	Human Integrin αVβ6 / Latent TGF-β1 Inhibitor Screening Kit (TR-FRET)
IT6-M82W9	Mouse	HEK293	Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT6-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free
IT6-M52E3	Mouse & Human	HEK293	Mouse & Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

総数量11

Integrin alpha V beta 6バックグランド

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
IDL-2965	IDL-2965	Phase 2 Clinical	Indalo Therapeutics Inc	Idiopathic Pulmonary Fibrosis; Metabolic Dysfunction-Associated Steatotic Liver Disease	詳細
Bexotegrast	PLN-74809	Phase 2 Clinical	Pliant Therapeutics Inc	Cholangitis, Sclerosing; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Respiratory Distress Syndrome, Adult	詳細
Nesvategrast	SF-0166; OTT-166(OcuTerra Therapeutics)	Phase 2 Clinical	OcuTerra Therapeutics Inc, Scifluor Life Sciences Inc	Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration	詳細
18F-αvβ6-Binding-Peptide	18F-αvβ6-BP	Phase 1 Clinical	National Cancer Institute, National Institutes Of Health	Breast Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Lung Neoplasms; Metastatic breast cancer; Pancreatic Neoplasms; Rectal Neoplasms	詳細
[18F]FP-R01-MG	[18F]FP-R01-MG-F2; [18F]FP-R01-MG	Phase 1 Clinical	Chinese Academy Of Medical Science & Peking Union Medical College, Pliant Therapeutics Inc, Stanford University	Brain metastases; Carcinoma, Non-Small-Cell Lung; Cholangitis, Sclerosing; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Pancreatic Neoplasms	詳細
Ga-68-Trivehexin	RAD-301	Phase 1 Clinical	Trimt GmbH	Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Ovarian Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms	詳細

レビュー

A***l2022-03-15
0評価
Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
Great communication from the Acro team--quickly received an email detailing the estimated delivery timeframe and asking if that timeframe was acceptable. Product was ready per the timeline provided by the Acro biosystems team and shipped. This was a new product for us (though we’ve used other acro biosystems products previously) and worked well for our intended use with Surface Plasmon Resonance (SPR). Thank you all!