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IRAK4

IRAK4 Product List

Product Category
Protein (5)
Product Status
Launched (5)
Species
Human (2)Canine (1)Mouse (1)Cynomolgus (1)
Tag
His Tag (4)GST Tag (1)
Conjugate
Unconjugated (5)

Cat. No.	Species	Host	Product Description
AI Compatible IR4-H5533	Human	InsectCells	Human IRAK4 Protein, GST Tag (active enzyme, HPLC verified)
AI Compatible IR4-H5546	Human	InsectCells	Human IRAK4 Protein, His Tag
AI Compatible IR4-M5544	Mouse	InsectCells	Mouse IRAK4 Protein, His Tag (active enzyme)
AI Compatible IR4-C5545	Canine	InsectCells	Canine IRAK4 Protein, His Tag (active enzyme)
AI Compatible IR4-C5546	Cynomolgus	InsectCells	Cynomolgus IRAK4 Protein, His Tag (active enzyme)

Total: 5

IRAK4 Background

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Fiztasovimab	NPC-21	Phase 2 Clinical	Nobelpharma Co Ltd	Cytomegalovirus Infections	Details
TRL-345	CMV-345; TRL-345	Phase 1 Clinical	Trellis Bioscience LLC	Cytomegalovirus Infections	Details