JAK1

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JAK1 詳細

Molecule Name

Tyrosine-protein kinase JAK1

分子の別称

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Drug Development Progress

治験薬の数46

市販薬剤の数13

研究＆開発段階Approved

ターゲットの別称

JAK1B，Tyrosine-protein kinase JAK1，JAK1，Janus Kinase 1，JAK1A，EC 2.7.10.2，JAK-1，JTK3，EC:2.7.10.2，EC 2.7.10

バックグランド

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

JAK1 製品リスト

Molecule	Cat. No.	Product Name	種	Host	Structure	Purity	Activity	Size&Price
JAK1	JA1-H5547	Human JAK1 Protein, His Tag	Human	InsectCells		SDS-PAGE		$360.00 50ug

JAK1 >

Human JAK1 Protein, His Tag

Cat. No. JA1-H5547

種

Human

Host

InsectCells

Purity

SDS-PAGE

$360.00

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治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Povorcitinib	INCB54707; INCB-54707; INCB054707; INCB-054707	Phase 3 Clinical	Incyte Corp	Angioedema; Asthma; Chronic Urticaria; Hidradenitis Suppurativa; Kidney Diseases; Prurigo Nodularis; Pruritus; Renal Insufficiency; Urticaria; Vitiligo	詳細
WXFL-10203614	WXFL-10203614	Phase 3 Clinical	Wuxi Apptec Co Ltd, Wuxi Fuxin Pharmaceutical Research And Development Co Ltd	Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic	詳細
TLL-018	TLL-018	Phase 3 Clinical	Tll Pharmaceutical Llc	Arthritis, Rheumatoid; Chronic Urticaria; Colitis, Ulcerative; Dermatitis, Atopic; Lupus Erythematosus, Systemic; Plaque psoriasis; Psoriasis; Urticaria	詳細
Pumecitinib	PG-011	Phase 3 Clinical	Prime Gene Therapeutics Co Ltd	Rhinitis, Allergic; Rhinitis, Allergic, Seasonal	詳細
Ruxolitinib (Taro Pharmaceuticals)		Phase 3 Clinical	Taro Pharmaceuticals Usa Inc	Dermatitis, Atopic; Hidradenitis Suppurativa	詳細
Ruxolitinib Gel(Hangzhou Zhongmei Huadong)	HDM3010; HDM-3010	Phase 3 Clinical	Hangzhou Zhongmei Huadong Pharmaceutical Co Ltd	Prurigo Nodularis; Vitiligo	詳細
BHV-8000	TLL-041; TLL041	Phase 3 Clinical	Hangzhou Highlightll Pharmaceutical Co Ltd	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Central Nervous System Diseases; Parkinson Disease	詳細
LW-402	LW-402	Phase 3 Clinical	Shanghai Longwood Biopharmaceuticals Co Ltd	Arthritis, Rheumatoid; Dermatitis, Atopic; Inflammatory Bowel Diseases; Spondylitis, Ankylosing; Vitiligo	詳細
VVN-461	VVN461LD; VVN-461; VVN461e; VVN-461-e	Phase 3 Clinical	VivaVision Biotech Inc	Dry Eye Syndromes; Inflammation; Postoperative inflammation; Uveitis; Uveitis, Anterior	詳細
Quecitinib	QY201; QY-201	Phase 3 Clinical	E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd	Alopecia Areata; Arthritis, Rheumatoid; Dermatitis, Atopic; Prurigo; Prurigo Nodularis; Psoriasis; Spondylitis, Ankylosing; Vitiligo	詳細
VC-005	VC-005	Phase 3 Clinical	Jiangsu Vcare Pharmatech Co Ltd	Alopecia Areata; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Eczema; Inflammatory Bowel Diseases; Joint Diseases; Spondylitis, Ankylosing; Vitiligo	詳細
Zemprocitinib	LNK01001; LNK-001; LNK001; LNK-207; EQ-121; LNK-01001	Phase 3 Clinical	Lynk Pharmaceutical (Hangzhou) Co Ltd	Arthritis, Rheumatoid; Dermatitis, Atopic; Spondylitis, Ankylosing	詳細
WXSH-0150	WXSH-0150; TUL-01101	Phase 2 Clinical	Zhuhai United Laboratories Co Ltd	Arthritis, Rheumatoid; Dermatitis, Atopic	詳細
NS-229	NS-229	Phase 2 Clinical	Neurosearch As	Eosinophilic Granulomatosis With Polyangiitis; Epilepsy	詳細
Ivarmacitinib sulfate Base gel(Jiangsu Hengrui Medicine)	SHR0302 base	Phase 2 Clinical	Jiangsu Hengrui Medicine Co Ltd	Vitiligo	詳細
Tofacitinib citrate (CAGE Bio)	CGB-500; CGB-501	Phase 2 Clinical	CAGE Bio Inc	Alopecia Areata; Dermatitis, Atopic	詳細
ALY-101	ALY-101	Phase 2 Clinical	Alys Pharmaceuticals Inc	Alopecia Areata; Dermatitis, Atopic; Eczema	詳細
TDM-180935	TDM-180935	Phase 2 Clinical	Jiaxing TechnoDerma Medicines Inc	Dermatitis, Atopic	詳細
AC-201	AC-201	Phase 2 Clinical	Accro Bioscience (Suzhou) Co Ltd	Lupus Erythematosus, Systemic; Plaque psoriasis; Psoriasis; Uveitis	詳細
H-018	H018; H-018	Phase 2 Clinical	Jiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co Ltd	Arthritis, Rheumatoid; Dermatitis, Atopic; Vitiligo	詳細
Fingolimod/Tofacitinib	FMX-114	Phase 2 Clinical	Vyne Therapeutics Inc	Dermatitis, Atopic	詳細
JYP-0061	JYP-0061	Phase 2 Clinical	Guangzhou Jiayue Pharmaceutical Technology Co Ltd	Alopecia Areata; Arthritis, Rheumatoid; Autoimmune Diseases; Demyelinating Diseases; Dermatitis, Atopic; Neuromyelitis Optica; Prurigo Nodularis; Spondylarthritis; Vitiligo	詳細
Londamocitinib Xinafoate	AZD-4604	Phase 2 Clinical	Astrazeneca Plc	Asthma	詳細
Lepzacitinib		Phase 2 Clinical	Aclaris Therapeutics Inc	Dermatitis, Atopic	詳細
LNK-01002	LNK01002; LNK-1000318	Phase 2 Clinical	Lynk Pharmaceutical (Hangzhou) Co Ltd	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential	詳細
Itacitinib	INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377	Phase 2 Clinical	Incyte Corp	Arthritis, Rheumatoid; Asthma; Bone Marrow Neoplasms; Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Chondrosarcoma; Colitis, Ulcerative; Colorectal Neoplasms; Cytokine Release Syndrome; Endometrial Neoplasms; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hemic and Lymphatic Diseases; Hodgkin Disease; Leiomyosarcoma; Leukemia; Leukemia, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Plasma Cell; Leukemia, Prolymphocytic, T-Cell; Liposarcoma; Liposarcoma, Myxoid; Lung Neoplasms; Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Plaque psoriasis; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-	詳細
Elsubrutinib/Upadacitinib	ABBV-599	Phase 1 Clinical	Abbvie Inc	Arthritis, Rheumatoid; Lupus Erythematosus, Systemic	詳細
CS-12192	CS12192	Phase 1 Clinical	Shenzhen Chipscreen Biosciences Co Ltd	Alopecia Areata; Autoimmune Diseases; Dermatitis, Atopic; Enteritis; Graft vs Host Disease; Lupus Erythematosus, Systemic; Multiple Sclerosis	詳細
FZJ-003	FZJ-003	Phase 1 Clinical	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd	Arthritis, Rheumatoid; Dermatitis, Atopic	詳細
Frevecitinib	VR-588; KN-002; KN-002 (Kinaset Therapeutics/Vectura)	Phase 1 Clinical	Vectura Ltd	Asthma; Pulmonary Disease, Chronic Obstructive	詳細
GLPG-3121	GLPG-3121	Phase 1 Clinical	Galapagos Nv		詳細
tofacitinib (3S Bio)	SSS-32	Phase 1 Clinical	3sbio Inc	Arthritis, Rheumatoid	詳細
LP-0184	LP-0184	Phase 1 Clinical	Leo Pharma A/S	Dermatitis, Atopic	詳細
Tofacitinib(Biora Therapeutics)	BT-600; PGN-600	Phase 1 Clinical	Progenity Inc	Colitis, Ulcerative	詳細
HHT-109	HHT-109	Phase 1 Clinical	Zhejiang Huahai Pharmaceutical Co Ltd	Arthritis, Rheumatoid	詳細
Tofacitinib Citrate Modified-Release Tablets(Taizhou Overseas Pharma)		Phase 1 Clinical	Taizhou Overseas Pharmaceuticals Co Ltd	Arthritis, Rheumatoid	詳細
Abrocitinib Oral Suspension(Pfizer)		Phase 1 Clinical	Pfizer Inc	Dermatitis, Atopic	詳細
Tofacitinib citrate (TWi Biotechnology)	IMG 003; AC-1101	Phase 1 Clinical	Twi Biotechnology Inc	Granuloma Annulare	詳細
Tofacitinib controlled release (Triastek)	T-21; T21; T-19	Phase 1 Clinical	Triastek Inc	Arthritis, Rheumatoid	詳細
GDC-0214	RG-6151; GDC-0214	Phase 1 Clinical	Genentech Inc	Asthma	詳細
QY-211	QY211; QY-211	Phase 1 Clinical	E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd	Dermatitis, Atopic; Eczema; Vitiligo	詳細
AQ-280	AQ-280	Phase 1 Clinical	Aqilion AB	Eosinophilic Esophagitis	詳細
PG-018	PG-018	Phase 1 Clinical	Prime Gene Therapeutics Co Ltd	Glomerulonephritis, Membranous; Nephrosis	詳細
TT-00420/Atezolizumab		Phase 1 Clinical	TransThera Sciences (Nanjing) Inc	Gastrointestinal Neoplasms	詳細
LBG-1600M		Phase 1 Clinical	Suzhou Longbotai Pharmaceutical Co Ltd	Dermatitis, Atopic	詳細
NIP-046	NIP-046	Phase 1 Clinical	National Institutes Of Pharmaceutical Research And Development Co Ltd	Arthritis, Rheumatoid; Chronic Urticaria	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Filgotinib Maleate	G-146034; GLPG-0634; G-146034-101; GS-6034	Approved	Galapagos Nv	Jyseleca	EU	Arthritis, Rheumatoid	Galapagos Nv	2020-09-24	Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Axial Spondyloarthritis; Behcet Syndrome; Colitis, Ulcerative; Crohn Disease; Glomerulonephritis, Membranous; Immunoglobulin G4-Related Disease; Inflammatory Bowel Diseases; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Myositis; Renal Insufficiency; Sjogren's Syndrome; Spondylitis, Ankylosing; Uveitis	詳細
Deuterated ruxolitinib	CTP-543; C-21543 phosphate; CTP-543 phosphate	Approved	Concert Pharmaceuticals Inc	LEQSELVI	United States	Alopecia Areata	Sun Pharmaceutical Industries Ltd	2024-07-25	Alopecia Areata; Hepatic Insufficiency; Renal Insufficiency	詳細
Peficitinib	ASP-015K; JNJ-54781532	Approved	Astellas Pharma Inc	Smyraf, 施觅福	Japan	Arthritis, Rheumatoid	Astellas Pharma Inc	2019-03-29	Arthritis, Rheumatoid; Colitis, Ulcerative; Psoriasis	詳細
Momelotinib Dihydrochloride	CYT-387; GS-0387; GSK-3070785	Approved	Cytopia Pty Ltd, Gilead Sciences Inc	Ojjaara, Omjjara	United States	Primary Myelofibrosis; Anemia	Glaxosmithkline Llc, Glaxosmithkline Plc	2023-09-15	Anemia; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms; Pancreatic Intraductal Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Splenomegaly; Thrombocythemia, Essential; VEXAS Syndome	詳細
Ivarmacitinib sulfate	SHR-0302; ARQ-252; ARQ-255	Approved	Jiangsu Hengrui Medicine Co Ltd	艾速达	Mainland China	Spondylitis, Ankylosing	Jiangsu Hengrui Medicine Co Ltd	2025-03-18	Alopecia Areata; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Eczema; Graft vs Host Disease; Hepatic Insufficiency; Lupus Erythematosus, Systemic; Lymphoma, T-Cell, Peripheral; Metastatic breast cancer; Non-radiographic axial spondyloarthritis; Sedation; Solid tumours; Spondylarthritis; Spondylitis, Ankylosing; Triple Negative Breast Neoplasms; Vitiligo	詳細
Gecacitinib Hydrochloride	ZG-0128; ZG-0163	Approved	Suzhou Zelgen Biosciences Co Ltd	泽普平	Mainland China	Primary Myelofibrosis	Suzhou Zelgen Biopharmaceuticals Co Ltd	2025-05-27	Alopecia Areata; Carcinoma, Non-Small-Cell Lung; Coronavirus Disease 2019 (COVID-19); Dermatitis, Atopic; Graft vs Host Disease; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Lupus Erythematosus, Systemic; Lymphoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Plaque psoriasis; Pneumonia; Polycythemia Vera; Primary Myelofibrosis; Solid tumours; Spondylitis, Ankylosing; Thrombocythemia, Essential; Vitiligo	詳細
Abrocitinib	PF-4965842; PF-04965842	Approved	Pfizer Inc	Cibinqo, CIBINQO, 希必可	United Kingdom	Dermatitis, Atopic	Pfizer Inc	2021-09-09	Alopecia Areata; Dermatitis; Dermatitis, Atopic; Eczema; Fatigue; Food Hypersensitivity; Genetic Diseases, Inborn; Granuloma Annulare; Hepatic Insufficiency; Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Plaque psoriasis; Post-Acute COVID-19 Syndrome; Prurigo; Prurigo Nodularis; Pruritus; Renal Insufficiency; Sarcoidosis; Skin Diseases; Skin Diseases, Eczematous; Skin Diseases, Genetic	詳細
Tofacitinib Citrate	CP-690550-10; CKD-374; Tasocitinib; CP-690550; AC-1101; IMG 003	Approved	Pfizer Inc	Jakvinus, Xeljanz, 尚杰	United States	Arthritis, Rheumatoid	Pf Prism Cv	2012-11-06	Alopecia; Alopecia Areata; Amyotrophic Lateral Sclerosis; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Axial Spondyloarthritis; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Depression; Dermatitis; Dermatitis, Atopic; Dermatomyositis; Down Syndrome; Dry Eye Syndromes; Eczema; Gastrointestinal Diseases; Glioblastoma; Granuloma Annulare; Granulomatous Disease, Chronic; Hepatic Insufficiency; Hidradenitis Suppurativa; Inflammation; Keratoconjunctivitis Sicca; Kidney Failure, Chronic; Lung Diseases, Interstitial; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Lymphoma, T-Cell, Cutaneous; Plaque psoriasis; Pneumonia; Psoriasis; Rejection of renal transplantation; Renal Insufficiency; Sacroiliitis; Sarcoidosis; Sarcoidosis, Pulmonary; Scleritis; Scleroderma, Systemic; Sjogren's Syndrome; Spondylitis; Spondylitis, Ankylosing; Uveitis; Vitiligo	詳細
Golidocitinib	NC-0322; AZD-4205; DZD-4205	Approved	Astrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd	高瑞哲	Mainland China	Lymphoma, T-Cell, Peripheral	Dizal (Jiangsu) Pharmaceutical Co Ltd	2024-06-18	Anemia, Aplastic; Carcinoma, Non-Small-Cell Lung; Epstein-Barr Virus Infections; Hematologic Diseases; Histiocytosis; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Extranodal NK-T-Cell; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Small Cell Lung Carcinoma; Virus Diseases	詳細
Upadacitinib Oral Solution(艾伯维)		Approved	Abbvie Inc	RINVOQ® LQ, RINVOQ LQ, Rinvoq Lq	United States	Dermatitis, Atopic; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Crohn Disease; Colitis, Ulcerative; Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Psoriatic	Abbvie Inc	2024-04-26	Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing	詳細
Upadacitinib	ABT-494	Approved	Abbott Laboratories	Rinvoq, Rinvoq Lq, RINVOQ LQ, 瑞福	United States	Arthritis, Rheumatoid	Abbvie Inc	2019-08-16	Alopecia Areata; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Behcet Syndrome; Blepharitis; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Giant Cell Arteritis; Hidradenitis Suppurativa; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Non-radiographic axial spondyloarthritis; Sleep Wake Disorders; Spondylarthritis; Spondylitis, Ankylosing; Takayasu Arteritis; Vitiligo	詳細
Baricitinib	LY-3009104; INCB-028050	Approved	Incyte Corp	艾乐明, Olumiant	EU	Arthritis, Rheumatoid	Eli Lilly Nederland BV	2017-02-13	Acute Lung Injury; Aicardi Goutieres syndrome; Alopecia Areata; Anhedonia; Arthritis, Juvenile; Arthritis, Rheumatoid; Cerebral Hemorrhage; Cholangitis, Sclerosing; Conjunctivitis; Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Depression; Depressive Disorder, Major; Dermatitis, Atopic; Dermatomyositis; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Graft vs Host Disease; Hepatic Insufficiency; HIV Infections; Infections; Job Syndrome; Lichen Planus; Lichen Planus, Oral; Liver Diseases; Lupus Erythematosus, Systemic; Lupus Nephritis; Lupus Vulgaris; Malignant Atrophic Papulosis; Myositis; Nephritis; Pemphigoid, Benign Mucous Membrane; Polymyalgia Rheumatica; Post-Acute COVID-19 Syndrome; Psoriasis; Pyoderma; Pyoderma Gangrenosum; Renal Insufficiency, Chronic; Sarcoidosis; Scleroderma, Diffuse; Severe Acute Respiratory Syndrome; Skin Diseases; Skin Diseases, Papulosquamous; Skin Ulcer; Vitiligo; Wounds and Injuries	詳細
Ruxolitinib Phosphate	INCB-18424; RUX; INCB 018424 phosphate; INCB-018424; INC-424; INCB-424	Approved	Incyte Corp	OPZELURA, Jakavi, Jakafi	United States	Primary Myelofibrosis	Incyte Corp	2011-11-16	Alopecia Areata; Anemia, Aplastic; Anemia, Sickle Cell; Arthritis, Rheumatoid; Autoimmune Lymphoproliferative Syndrome; beta-Thalassemia; Bone Marrow Neoplasms; Breast Carcinoma In Situ; Breast Neoplasms; Cachexia; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Castleman Disease; Chronic eosinophilic leukemia (CEL); Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Cytokine Release Syndrome; Dermatitis; Dermatitis, Atopic; Eczema; Eosinophilia; Exanthema; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hepatomegaly; Hidradenitis Suppurativa; HIV Infections; Hodgkin Disease; Hypereosinophilic Syndrome; Hyperplasia; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Chronic; Leukemia, Neutrophilic, Chronic; Leukemia	詳細

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治験薬に関する情報

市販薬剤に関する情報