KIR2DL5A

Killer cell immunoglobulin-like receptor 2DL5(KIR2DL5), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism-KIR2DL5A and KIR2DL5B that vary by only 2 aa in domain and 1 aa in signal peptide. KIR2DL5 and KIR2DL4 form a subfamily, which have longer cytoplasmic tails than other KIR, and each has one D0 and one D2-type Ig-like domain.