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KLRG1

KLRG1 詳細

英語名	Killer cell lectin-like receptor subfamily G member 1	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
研究＆開発段階	Phase 3 Clinical

英語名	Killer cell lectin-like receptor subfamily G member 1
ターゲットの別称	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 3 Clinical

KLRG1 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (1)Mouse (1)Cynomolgus (3)
タグ
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
マーカー
Unconjugated (4)Biotin-labeled (1)

製品番号	種	発現システム	製品説明
HOT KL1-H5249	Human	HEK293	Human KLRG1 Protein, His Tag
HOT KL1-M5249	Mouse	HEK293	Mouse KLRG1 Protein, His Tag (MALS & SPR verified)
HOT KL1-C5243	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, His Tag (SPR verified)
HOT KL1-C5269	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, Fc Tag (SPR verified)
KL1-C82Q4	Cynomolgus	HEK293	Biotinylated Cynomolgus KLRG1 Protein, Avitag™,His Tag

総数量5

KLRG1バックグランド

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.