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LAG-3

LAG-3

LAG-3 詳細

Molecule Name
Lymphocyte activation gene 3 protein
分子の別称
LAG3,CD223,FDC
Drug Development Progress
治験薬の数31
市販薬剤の数1
研究＆開発段階Approved
ターゲットの別称
Lymphocyte activation gene 3 protein，LAG3，Lymphocyte Activating 3，Lymphocyte-Activation Gene 3，CD223 Antigen，Protein FDC，CD223，LAG-3，FDC，sLAG-3
バックグランド
Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

LAG-3 製品リスト

Species
  • Human（9）
  • Cynomolgus（5）
  • Mouse（4）
  • Canine（1）
  • Rat（1）
Tag
  • His Tag（7）
  • Fc Tag（3）
  • His Tag & Avi Tag（3）
  • Mouse IgG Fc Tag（3）
  • Fc Tag & Avi Tag（2）
  • Llama IgG Fc Tag（1）
  • Mouse IgG Fc Tag & Avi Tag（1）
Host
  • HEK293（20）
Conjugate
  • Unconjugated（12）
  • Biotin-labeled（7）
  • PE Labeled（1）
Grade
  • RUO（20）
Low Endotoxin
  • Yes（6）
  • No（14）
MoleculeCat. No.Product Name種HostStructurePurityActivitySize&Price
LAG-3
HOTAIDD‑Ready
LA3-H5255
Human LAG3 / CD223 Protein, Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISABLI

$340.00

100ug
LAG-3
HOTAIDD‑Ready
LA3-H5222
Human LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPRBLI

$370.00

100ug
LAG-3
HOT
LA3-M52H5
Mouse LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
Mouse
HEK293
MALSSDS-PAGE
ELISA

$360.00

100ug
LAG-3
HOTAvitag
LA3-H82E9
Biotinylated Human LAG-3 / CD223 Protein, His,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
LAG-3
HOTAvitag
LA3-H82F3
Biotinylated Human LAG-3 / CD223 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$360.00

25ug
LAG-3
LA3-C5252
Cynomolgus LAG-3 / CD223 Protein, Fc Tag, low endotoxin (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISAFlow

$360.00

100ug
LAG-3
LA3-C52A0
Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag (HPLC verified)
Cynomolgus
HEK293
HPLCSDS-PAGE
ELISA

$420.00

100ug
LAG-3
LA3-C52H7
Canine LAG-3 / CD223 Protein, His Tag (MALS verified)
Canine
HEK293
MALSSDS-PAGE

$360.00

100ug
LAG-3
LA3-C8258
Biotinylated Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
LAG-3
Avitag
LA3-C82E5
Biotinylated Cynomolgus LAG-3 / CD223 Protein, His,Avitag™ (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
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ライセンシング

プロジェクト薬物タイプ治療分野適応症ステージエリア
LAG-3 mAbMonospecific antibodyOncology/CancerAdvanced solid tumorPhase IGlobal
プロジェクト
LAG-3 mAb
薬物タイプ
Monospecific antibody
治療分野
Oncology/Cancer
適応症
Advanced solid tumor
ステージ
Phase I
エリア
Global
Resources

治験薬に関する情報

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FianlimabREGN-3767Phase 3 ClinicalRegeneron Pharmaceuticals Inc
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AlcestobartLBL-007Phase 2 ClinicalLeads Biolabs Inc
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NegalstobartIBI-110Phase 2 Clinical
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IMP-761IMP-761Phase 1 ClinicalImmutep
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TQB-2252TQB-2252; TQB2252Phase 1 ClinicalChia Tai Tianqing (Guangzhou) Pharmaceutical Co Ltd
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AK-137AK137; AK-137Phase 1 Clinical
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市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Nivolumab/RelatlimabBMS-986213; BMS-936558/BMS-986016ApprovedBristol-Myers Squibb CompanyOPDUALAGUnited StatesMelanomaBristol-Myers Squibb Company2022-03-18
Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Skin Melanoma; Solid tumours; Stomach Neoplasms
詳細
Customer Reviews
  • N***r2022-11-08
    Biotinylated Human LAG-3 / CD223 Protein, His,Avitag™ (MALS verified)
    Ordered this reagent for a binding ELISA performed for a client. Client had questions about extending the reagent expiry and getting extra documentation provided for a GMP project. Acros customer service was great in answering all of my questions and providing documentation within just a few mins. I was provided with the COA and a memo ensuring the expiry could be extended from data that Acros had collected. I was also able to talk to other scientists on the technical side of their customer services and ensure that what I was relaying to the client was accurate. Really helped out on this project and the client was very happy! Thank you Acros!
  • 1***12019-11-07
    Human LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
    I purchased Acro's protein many times for experiments. LAG3 was used mostly, and the titer after immunization can reach more than 100,000. It is a very good product.
  • 1***92019-10-11
    Human LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
    We purchased ACRO's Human LAG3-mFc protein, and we tested its affinity with the antibody on Biacore T200. The results showed that the affinity was within the normal range, and the protein bioactivity is very good!
  • 1***62019-10-11
    Human LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
    The protein was purchased for my study. It has good purity, which ensured that we obtained high-value antiserum in the animal immunization experiments. We performed multiple batches of immunization. They were stable and had good immune effect.
  • 1***22019-09-26
    Human LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
    I used this protein as an immune antigen in antibody development project. We obtained a pretty high serum titer. We purchased several batches of the protein, and performed multiple experiments. It proved that there was basically no difference among the batches.