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LAIR-1

LAIR-1 詳細

英語名	Leukocyte-associated immunoglobulin-like receptor 1	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	Immunoglobulin Heavy Chain Variable Region，HLAIR1，LAIR1，Leukocyte Associated Immunoglobulin Like Receptor 1，CD305 Antigen，hLAIR1，CD305，Leukocyte-Associated Ig-Like Receptor 1
研究＆開発段階	Phase 2 Clinical

英語名	Leukocyte-associated immunoglobulin-like receptor 1
ターゲットの別称	Immunoglobulin Heavy Chain Variable Region，HLAIR1，LAIR1，Leukocyte Associated Immunoglobulin Like Receptor 1，CD305 Antigen，hLAIR1，CD305，Leukocyte-Associated Ig-Like Receptor 1
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

LAIR-1 製品リスト

属性
Protein (8)
製品ライブラリ
オンライン (8)
種
Human (5)Rhesus macaque (1)Mouse (2)
タグ
His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)Mouse IgG Fc Tag (3)Fc Tag & Avi Tag (1)
マーカー
Unconjugated (6)Biotin-labeled (2)

製品番号	種	発現システム	製品説明
HOT CD5-H52H1	Human	HEK293	Human LAIR1 / CD305 Protein, His Tag
HOT LA1-H82E3	Human	HEK293	Biotinylated Human LAIR1 / CD305 Protein, His,Avitag™
HOT LA1-H82F5	Human	HEK293	Biotinylated Human LAIR1 / CD305 Protein, Fc,Avitag™ (MALS verified)
HOT LA1-M52H3	Mouse	HEK293	Mouse LAIR1 / CD305 Protein, His Tag (MALS verified)
LA1-H5252	Human	HEK293	Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)
LA1-H5253	Human	HEK293	Human LAIR-1 Protein, Mouse IgG2a Fc Tag
LA1-M5254	Mouse	HEK293	Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
LA1-C52A3	Rhesus macaque	HEK293	Rhesus macaque LAIR-1 / CD305 Protein, Mouse IgG2a Fc Tag

総数量8

LAIR-1バックグランド

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

LAIR-1分子の別称

LAIR1,CD305

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
NC-410	NC-410	Phase 2 Clinical	Nextcure Inc	Colorectal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms	詳細
NGM-438	NGM-438	Phase 1 Clinical	Merck & Co Inc, NGM Biopharmaceuticals Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細