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Leptin R

Leptin R 詳細

英語名Leptin receptor市販薬剤の数1
治験薬の数3ターゲットの別称CD295，OB receptor，LEPR，HuB219，DB，Leptin Receptor，LEP-R，OB-R，OBR，CD295 Antigen，LEPRD，Receptors， Leptin
研究＆開発段階Approved
英語名Leptin receptor
ターゲットの別称CD295，OB receptor，LEPR，HuB219，DB，Leptin Receptor，LEP-R，OB-R，OBR，CD295 Antigen，LEPRD，Receptors， Leptin
市販薬剤の数1
治験薬の数3
研究＆開発段階Approved

Leptin R 製品リスト

  • 属性

    Protein (2)

  • 製品ライブラリ

    オンライン (2)

  • 種

    Human (2)

  • タグ

    Fc Tag (1)His Tag & Avi Tag (1)

  • マーカー

    Unconjugated (1)Biotin-labeled (1)

製品番号種発現システム製品説明タンパク質の構造純度特性
LER-H5252
Human
HEK293
Human Leptin R / CD295 Protein, Fc Tag
LER-H82E3
Human
HEK293
Biotinylated Human Leptin R Protein, His,Avitag™
総数量2
  • 1
お問い合わせ

Leptin Rバックグランド

Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Leptin R分子の別称

LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
MibavademabREGN-4461Phase 3 ClinicalRegeneron Pharmaceuticals IncAmenorrhea; Lipodystrophy, Congenital Generalized; Lipodystrophy, Familial Partial; Monogenic obesity; Obesity
詳細
RG-6436RG6436; RG-6436Phase 1 ClinicalEnterprise Therapeutics Ltd, Genentech IncUrinary Tract Infections
詳細
ERX-1000ERX-1000Phase 1 ClinicalERX Pharmaceuticals IncObesity
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
MetreleptinKTR-103; AC-164594ApprovedAmylin Pharmaceutical, Astrazeneca Plc, Bristol-Myers Squibb CompanyMetreleptin [SHIONOGI], MyaleptaJapanLipodystrophyShionogi & Co Ltd2013-03-25Diabetes Mellitus; Diabetes Mellitus, Type 1; HIV Infections; Hyperlipidemias; Insulin Resistance; Lipodystrophy; Lipodystrophy, Congenital Generalized; Lipodystrophy, Familial Partial; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight
詳細

レビュー

  • B***™2026-07-22
    0評価
    Biotinylated Human Leptin R Protein, His,Avitag™
    This product performed really well in our assay. We observed improved sensitivity when using it as a capture reagent, likely due to its fragment format. The quality and performance were excellent, and I would recommend it for applications requiring sensitive leptin receptor detection.
  • 詳細
  • 製品リスト
  • 市販薬剤に関する情報
  • レビュー
  • 治験薬に関する情報