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LIGHT

LIGHT 詳細

英語名	Tumor necrosis factor superfamily member 14	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
研究＆開発段階	Phase 2 Clinical

英語名	Tumor necrosis factor superfamily member 14
ターゲットの別称	CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 2 Clinical

LIGHT 製品リスト

属性
Protein (6)Cell (1)
製品ライブラリ
オンライン (7)
種
Human (5)Cynomolgus (1)Mouse (1)
タグ
Mouse IgG Fc Tag (1)His Tag (4)Fc Tag (1)- (1)
マーカー
Unconjugated (6)- (1)

製品番号	種	発現システム	製品説明
HOT LIT-H5242	Human	HEK293	Human LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)
HOT LIT-H5269	Human	HEK293	Human LIGHT / TNFSF14 Protein, Fc Tag, active trimer, low endotoxin (MALS verified)
HOT LIT-M5243	Mouse	HEK293	Mouse LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)
HOT LIT-C5244	Cynomolgus	HEK293	Cynomolgus LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)
LIT-H5243	Human	HEK293	Human LIGHT / TNFSF14 Protein, His Tag, Ultra Low Endotoxin (MALS verified)
LIT-H5256	Human	HEK293	Human LIGHT / TNFSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin
SCCHO-ATP109	Human	CHO	CHO/Human LIGHT Stable Cell Line

総数量7

LIGHTバックグランド

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

LIGHT分子の別称

CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Quisovalimab	CERC-002; AEVI-002; MDGN-002; SAR-252067; AVTX-002	Phase 2 Clinical	Kyowa Hakko Kirin Co Ltd, La Jolla Pharmaceutical Company	Acute Lung Injury; Asthma; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Respiratory Distress Syndrome, Adult	詳細

レビュー

E***a2021-09-23
1評価
Human LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)
We use this protein as an ELISA standard. We are interested in quantifying soluble LIGHT concentration from human serum. This active form of the protein perfectly binds its receptors and policlonal antibodies. The standard curve obtained is highly reproducible. It was very easy to find all the information in the web of AcroBiosystems and to download the CoA, which was also very descriptive.