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LILRB2

LILRB2 詳細

英語名	Leukocyte immunoglobulin-like receptor subfamily B member 2	市販薬剤の数	0
治験薬の数	11	ターゲットの別称	Leukocyte immunoglobulin-like receptor 2，CD85 antigen-like family member D，Immunoglobulin-like transcript 4，ILT-4，Monocyte/macrophage immunoglobulin-like receptor 10，MIR-10，CD_antigen: CD85d，LILRB2，Leukocyte Immunoglobulin Like Receptor B2，Leucocyte Ig-Like Receptor B2，MIR10，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 2，Ig-Like Transcript 4，Myeloid Inhibitory Receptor 10，CD85d Antigen，ILT4，LIR2，CD85d，LIR-2，LIRB2
研究＆開発段階	Phase 2 Clinical

英語名	Leukocyte immunoglobulin-like receptor subfamily B member 2
ターゲットの別称	Leukocyte immunoglobulin-like receptor 2，CD85 antigen-like family member D，Immunoglobulin-like transcript 4，ILT-4，Monocyte/macrophage immunoglobulin-like receptor 10，MIR-10，CD_antigen: CD85d，LILRB2，Leukocyte Immunoglobulin Like Receptor B2，Leucocyte Ig-Like Receptor B2，MIR10，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 2，Ig-Like Transcript 4，Myeloid Inhibitory Receptor 10，CD85d Antigen，ILT4，LIR2，CD85d，LIR-2，LIRB2
市販薬剤の数	0
治験薬の数	11
研究＆開発段階	Phase 2 Clinical

LILRB2 製品リスト

属性
Protein (6)
製品ライブラリ
オンライン (6)
種
Human (4)Cynomolgus (2)
タグ
His Tag (2)Fc Tag & Avi Tag (1)His Tag & Avi Tag (2)Fc Tag (1)
マーカー
Unconjugated (3)Biotin-labeled (3)

製品番号	種	発現システム	製品説明
HOT LI2-H5220	Human	HEK293	Human LILRB2 / CD85d / ILT4 Protein, His Tag, low endotoxin (MALS verified)
HOT LI2-H5253	Human	HEK293	Human LILRB2 / CD85d / ILT4 Protein, Fc Tag (MALS verified)
HOT LI2-H82E7	Human	HEK293	Biotinylated Human LILRB2 / CD85d / ILT4 Protein, His,Avitag™ (MALS verified)
HOT LI2-H82F5	Human	HEK293	Biotinylated Human LILRB2 / CD85d / ILT4 Protein, Fc,Avitag™ (MALS verified)
LI2-C52H3	Cynomolgus	HEK293	Cynomolgus LILRB2 / CD85d / ILT4 Protein, His Tag
LI2-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus LILRB2 / CD85d / ILT4 Protein, His,Avitag™

総数量6

LILRB2バックグランド

Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

LILRB2分子の別称

LILRB2,ILT4,LIR2,MIR10,CD85d

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
LILRB2 mAb - 01	PCC	Monoclonal	Humanized Mouse	Solid Tumor	Solid tumor

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Polzastobart	JTX-8064	Phase 2 Clinical	Jounce Therapeutics Inc	Neoplasms	詳細
IO-108	IO-108	Phase 2 Clinical	Yiming Biomedical Technology (Hangzhou) Co Ltd	Liver Neoplasms; Solid tumours	詳細
MK-4830	MK-4830	Phase 2 Clinical	Agenus Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Cystadenocarcinoma, Serous; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Ovarian Neoplasms; Solid tumours	詳細
SPX-303	SPX-303	Phase 2 Clinical	SparX Biopharmaceutical Corp	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	詳細
OR-502	OR502; OR-502	Phase 2 Clinical	OncoResponse Inc	Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Skin Melanoma; Solid tumours	詳細
NGM-707	NGM-707	Phase 2 Clinical	Merck & Co, NGM Biopharmaceuticals Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Glioblastoma; Melanoma; Mesothelioma; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms	詳細
AK-150 (Akeso)	AK150; AK-150	Phase 1 Clinical		Solid tumours	詳細
CHS-1000	CHS-1000	Phase 1 Clinical	Coherus Biosciences Inc	Solid tumours	詳細
BMS-986406	BMS-986406; ONO-7226	Phase 1 Clinical	Bristol-Myers Squibb Company	Neoplasms	詳細
CDX-585	CDX-585; BSI-585	Phase 1 Clinical	Biosion Inc, Celldex Therapeutics	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Solid tumours; Stomach Neoplasms	詳細
ES-009	ES-009	Phase 1 Clinical	Elpiscience (Shanghai) Biopharma Ltd	Neoplasms; Solid tumours	詳細