言語を選択

MAdCAM-1

MAdCAM-1 詳細

英語名	Mucosal addressin cell adhesion molecule-1	市販薬剤の数	1
治験薬の数	4	ターゲットの別称	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
研究＆開発段階	Approved

英語名	Mucosal addressin cell adhesion molecule-1
ターゲットの別称	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
市販薬剤の数	1
治験薬の数	4
研究＆開発段階	Approved

MAdCAM-1 製品リスト

属性
Protein (7)Cell (1)
製品ライブラリ
オンライン (8)
種
Human (4)Cynomolgus (2)Mouse (2)
タグ
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag (3)His Tag & Avi Tag (2)- (1)
マーカー
Unconjugated (4)Biotin-labeled (3)- (1)

製品番号	種	発現システム	製品説明
HOT MAM-H5253	Human	HEK293	Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)
HOT MAM-H52H4	Human	HEK293	Human MAdCAM-1 Protein, His Tag (MALS & SPR verified)
HOT MAM-H8251	Human	HEK293	Biotinylated Human MAdCAM-1 Protein, Fc,Avitag™ (MALS verified)
CCHO-ATP241	Human	CHO	CHO/Human MAdCAM-1 Stable Cell Line
MAM-M52H3	Mouse	HEK293	Mouse MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)
MAM-M82E3	Mouse	HEK293	Biotinylated Mouse MAdCAM-1 Protein, His,Avitag™ (MALS verified)
MAM-C52H3	Cynomolgus	HEK293	Cynomolgus MAdCAM-1 Protein, His Tag, low endotoxin
MAM-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus MAdCAM-1 Protein, His,Avitag™ (MALS verified)

総数量8

MAdCAM-1バックグランド

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

MAdCAM-1分子の別称

MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Colitis, Ulcerative; Crohn Disease; Fatty Liver; Ileitis	詳細
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	詳細
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	詳細
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	詳細