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Melanotransferrin

Melanotransferrin 詳細

英語名	Melanotransferrin	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2
研究＆開発段階	Phase 1 Clinical

英語名	Melanotransferrin
ターゲットの別称	Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 1 Clinical

Melanotransferrin 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (1)Cynomolgus (1)
タグ
His Tag (2)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
MEN-H5223	Human	HEK293	Human Melanotransferrin / CD228 Protein, His Tag (MALS verified)
MEN-C52H3	Cynomolgus	HEK293	Cynomolgus Melanotransferrin / CD228 Protein, His Tag, low Endotoxin (MALS verified)

総数量2

Melanotransferrinバックグランド

Melanotransferrin (MTF), also known as CD228, P97, MELTF and MFI2, is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. MTF expression is low in normal tissues but high in tumor and embryonic tissues. In melanoma MTF is associated with tumor metastasis and angiogenesis and upregulated in lung cancer tissue and cell lines. In the brain MTF is expressed in capillary endothelium but also in the reactive microglia associated with senile plaques in Alzheimer's disease (AD).

Melanotransferrin分子の別称

Melanotransferrin,CD228,MFI2,MAP97,MELTF

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
BA-1302	BA-1302; BA1302	Phase 1 Clinical	Shandong Boan Biotechnology Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma; Pancreatic Neoplasms; Solid tumours	詳細
SGN-BB228	SGN-BB228; PF-08046049; BB-228; PRS-346	Phase 1 Clinical	Pieris Pharmaceuticals	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma; Mesothelioma; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	詳細