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MERTK

MERTK 詳細

英語名	Tyrosine-protein kinase Mer	市販薬剤の数	1
治験薬の数	8	ターゲットの別称	EC 2.7.10，MER，MERTK，C-Mer Proto-Oncogene Tyrosine Kinase，Receptor Tyrosine Kinase MerTK，Tyrosine-Protein Kinase Mer，EC 2.7.10.1，STK Kinase，EC:2.7.10.1，Proto-oncogene c-Mer，MER Proto-Oncogene， Tyrosine Kinase，MER Receptor Tyrosine Kinase，Tyro12，C-Eyk，C-Mer，RP38，c-Mer Tyrosine Kinase
研究＆開発段階	Approved

英語名	Tyrosine-protein kinase Mer
ターゲットの別称	EC 2.7.10，MER，MERTK，C-Mer Proto-Oncogene Tyrosine Kinase，Receptor Tyrosine Kinase MerTK，Tyrosine-Protein Kinase Mer，EC 2.7.10.1，STK Kinase，EC:2.7.10.1，Proto-oncogene c-Mer，MER Proto-Oncogene， Tyrosine Kinase，MER Receptor Tyrosine Kinase，Tyro12，C-Eyk，C-Mer，RP38，c-Mer Tyrosine Kinase
市販薬剤の数	1
治験薬の数	8
研究＆開発段階	Approved

MERTK 製品リスト

属性
Protein (5)
製品ライブラリ
オンライン (5)
種
Human (2)Mouse (2)Cynomolgus (1)
タグ
His Tag (2)Fc Tag (3)
マーカー
Unconjugated (5)

製品番号	種	発現システム	製品説明
HOT MEK-H5253	Human	HEK293	Human MERTK / Mer Protein, Fc Tag
HOT MEK-H52H6	Human	HEK293	Human MERTK / Mer Protein, His Tag
HOT MEK-M52H9	Mouse	HEK293	Mouse MERTK / Mer Protein, His Tag (MALS verified)
MEK-M5253	Mouse	HEK293	Mouse MERTK / Mer Protein, Fc Tag (MALS verified)
MEK-C5253	Cynomolgus	HEK293	Cynomolgus MERTK / Mer Protein, Fc Tag (MALS verified)

総数量5

MERTKバックグランド

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

MERTK分子の別称

MERTK,Mer

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Sitravatinib	MG-516; MG-91516; MGCD-516; IND-155305; MGCD-0516	Phase 3 Clinical	Mirati Therapeutics Inc	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Hepatic Insufficiency; Kidney Neoplasms; Liposarcoma; Lung Diseases; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Oral Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Ureteral Neoplasms; Uterine Cervical Neoplasms; Uveal melanoma	詳細
MRX-2843	UNC-2371; UNC-2025; MRX-2843	Phase 2 Clinical	University Of North Carolina At Chapel Hill	Carcinoma, Non-Small-Cell Lung; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Neoplastic Processes; Pathologic Processes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours	詳細
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	詳細
Tamnorzatinib	ONO-7475	Phase 2 Clinical	Ono Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pancreatic Neoplasms; Solid tumours	詳細
Adrixetinib	Q-702	Phase 2 Clinical	Lead Discovery Center GmbH, Max Planck Institute of Biochemistry, Vichem Chemie	Blastic Plasmacytoid Dendritic Cell Neoplasm; Carcinoma, Hepatocellular; Central Nervous System Lymphoma; Erdheim-Chester Disease; Esophageal Neoplasms; Graft vs Host Disease; Hematologic Neoplasms; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms; Neoplasms, Plasma Cell; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms; Waldenstrom Macroglobulinemia	詳細
INCB-081776	INCB-81776; INCB-081776	Phase 1 Clinical	Incyte Corp	Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
Nifitinib Tosilate		Phase 1 Clinical	Sichuan University, Yangzijiang Pharmaceutical Group Sichuan Hairong Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung	詳細
NPS-1034	HOPE-777; KDDF-201111-02		Neopharma Ltd		詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin	詳細