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MMP-9

MMP-9 詳細

英語名	Matrix metalloproteinase 9	市販薬剤の数	0
治験薬の数	3	ターゲットの別称	Type V Collagenase，Gelatinase B，EC 3.4.24.35，MANDP2，Matrix Metalloproteinase 9，CLG4B，MMP9，Matrix Metallopeptidase 9，Matrix Metalloproteinase 9 (Gelatinase B， 92kDa Gelatinase， 92kDa Type IV Collagenase)，GELB，Matrix Metalloproteinase-9，92 KDa Type IV Collagenase，Macrophage Gelatinase，92 kDa gelatinase，MMP-9，Matrix Metallopeptidase 9 (Gelatinase B， 92kDa Gelatinase， 92kDa Type IV Collagenase)，EC:3.4.24.35，EC 3.4.24
研究＆開発段階	Phase 3 Clinical

英語名	Matrix metalloproteinase 9
ターゲットの別称	Type V Collagenase，Gelatinase B，EC 3.4.24.35，MANDP2，Matrix Metalloproteinase 9，CLG4B，MMP9，Matrix Metallopeptidase 9，Matrix Metalloproteinase 9 (Gelatinase B， 92kDa Gelatinase， 92kDa Type IV Collagenase)，GELB，Matrix Metalloproteinase-9，92 KDa Type IV Collagenase，Macrophage Gelatinase，92 kDa gelatinase，MMP-9，Matrix Metallopeptidase 9 (Gelatinase B， 92kDa Gelatinase， 92kDa Type IV Collagenase)，EC:3.4.24.35，EC 3.4.24
市販薬剤の数	0
治験薬の数	3
研究＆開発段階	Phase 3 Clinical

MMP-9 製品リスト

属性
Protein (6)
製品ライブラリ
オンライン (6)
種
Human (4)Mouse (1)Cynomolgus (1)
タグ
His Tag (6)
マーカー
Unconjugated (6)

製品番号	種	発現システム	製品説明
HOT MM9-H5221	Human	HEK293	Human MMP-9 Protein, His Tag (Pro-form)
HOT MM9-H5229	Human	HEK293	Human MMP-9 Protein, His Tag (Pro-form) (MALS verified)
HOT MM9-H52H9	Human	HEK293	Human MMP-9 (20-707) Protein, His Tag (Pro-form, MALS verified)
HOT MM9-M52H1	Mouse	HEK293	Mouse MMP-9 (20-471) Protein, His Tag (Pro-form, MALS verified)
MM9-H52H8	Human	HEK293	Human MMP-9 (107-707) (Q279R) Protein, His Tag (active enzyme)
MM9-C52H3	Cynomolgus	HEK293	Cynomolgus MMP-9 Protein, His Tag (Pro-form)

総数量6

MMP-9バックグランド

Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

MMP-9分子の別称

MMP9,CLG4B,GELB,MANDP2,Gelatinase B

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Andecaliximab	GS-5745	Phase 3 Clinical	Gilead Inc	Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colitis, Ulcerative; Colorectal Neoplasms; Crohn Disease; Cystic Fibrosis; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Myositis Ossificans; Ossification, Heterotopic; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Spinal Cord Injuries; Stomach Neoplasms	詳細
AQU-005	AQU-005; NMAQU-005; NM-AQU-005	Phase 1 Clinical	Aquilus Pharmaceuticals	Neuralgia	詳細
CALY-001	CALY-001	Clinical	Calypso Biotech Bv	Crohn Disease; Inflammatory Bowel Diseases	詳細