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NCAM-1

NCAM-1 詳細

英語名	Neural cell adhesion molecule 1	市販薬剤の数	0
治験薬の数	6	ターゲットの別称	Neural cell adhesion molecule 1，CD56，NCAM1，NCAM，Neural Cell Adhesion Molecule， NCAM，CD56 Antigen，N-CAM-1，MSK39，NCAM-1，Antigen Recognized By Monoclonal Antibody 5.1H11
研究＆開発段階	Phase 2 Clinical

英語名	Neural cell adhesion molecule 1
ターゲットの別称	Neural cell adhesion molecule 1，CD56，NCAM1，NCAM，Neural Cell Adhesion Molecule， NCAM，CD56 Antigen，N-CAM-1，MSK39，NCAM-1，Antigen Recognized By Monoclonal Antibody 5.1H11
市販薬剤の数	0
治験薬の数	6
研究＆開発段階	Phase 2 Clinical

NCAM-1 製品リスト

属性
Protein (9)
製品ライブラリ
オンライン (9)
種
Human (8)Mouse (1)
タグ
His Tag (5)Fc Tag (2)His Tag & Avi Tag (1)Llama IgG Fc Tag (1)
マーカー
Unconjugated (4)Biotin-labeled (1)FITC Labeled (2)AF488 Labeled (1)AF647 Labeled (1)

製品番号	種	発現システム	製品説明
HOT NC1-H5223	Human	HEK293	Human NCAM-1 / CD56 Protein, His Tag, low endotoxin (MALS verified)
HOT NC1-H5253	Human	HEK293	Human NCAM-1 / CD56 Protein, Fc Tag (MALS verified)
HOT NC1-H82E3	Human	HEK293	Biotinylated Human NCAM-1 / CD56 Protein, His,Avitag™ (MALS verified)
HOT NC1-HF2H5	Human	HEK293	FITC-Labeled Human NCAM-1 / CD56 Protein, His Tag
NC1-H5254	Human	HEK293	Human NCAM-1 / CD56 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
NC1-HA2H3	Human	HEK293	Alexa Fluor™ 488-Labeled Human NCAM-1 / CD56 Protein, His TagStar Staining (HPLC verified)
NC1-HA2H4	Human	HEK293	Alexa Fluor™ 647-Labeled Human NCAM-1 / CD56 Protein, His TagStar Staining (HPLC verified)
NC1-HF256	Human	HEK293	FITC-Labeled Human NCAM-1 / CD56 Protein, Fc Tag
NC1-M52H4	Mouse	HEK293	Mouse NCAM-1 / CD56 Protein, His Tag

総数量9

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NCAM-1バックグランド

NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways.

NCAM-1分子の別称

CD56,MSK39,NCAM1,N-CAM-1

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Lorvotuzumab mertansine	BB-10901; IMGN-901; huN-901-DM1; IMGN-901-TAP; huN-901-SPP-DM1	Phase 2 Clinical	Immunogen Inc	Carcinoma, Merkel Cell; Leukemia; Multiple Myeloma; Neuroblastoma; Neurofibrosarcoma; Ovarian Neoplasms; Pulmonary Blastoma; Rhabdomyosarcoma; Sarcoma, Synovial; Small Cell Lung Carcinoma; Wilms Tumor	詳細
EB-DART-NK01	EB-DART-NK01	Phase 2 Clinical	Beijing Biotech	Small Cell Lung Carcinoma	詳細
CUBT-906	CUBT-906	Phase 2 Clinical	Curative Biotechnology Inc	Glioblastoma	詳細
GD2/CD56 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR GD2/CD56	Phase 2 Clinical	Shenzhen Geno-Immune Medical Institute	Neoplasms	詳細
IN-B015	IN-B-015; IN-B00004	Phase 1 Clinical	HK inno.N Corporation	Neoplasms	詳細
DXC-006	DXC-006; DAC-006	Phase 1 Clinical	Hangzhou Dac Biotech Company Ltd	Hematologic Neoplasms; Lung Neoplasms; Solid tumours	詳細