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Nectin-4

Nectin-4 詳細

英語名	Nectin-4	市販薬剤の数	1
治験薬の数	29	ターゲットの別称	PRR4，LNIR，Nectin cell adhesion molecule 4，PVRL4，Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4，NECTIN4，Poliovirus Receptor-Related 4，Nectin-4，Nectin 4，EDSS1
研究＆開発段階	Approved

英語名	Nectin-4
ターゲットの別称	PRR4，LNIR，Nectin cell adhesion molecule 4，PVRL4，Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4，NECTIN4，Poliovirus Receptor-Related 4，Nectin-4，Nectin 4，EDSS1
市販薬剤の数	1
治験薬の数	29
研究＆開発段階	Approved

Nectin-4 製品リスト

属性
Protein (24)Beads (1)Cell (1)Antibody (1)
製品ライブラリ
オンライン (27)
種
Human (15)Mouse (6)Cynomolgus (4)Rat (2)
タグ
His Tag (8)His Tag & Avi Tag (8)Fc Tag (4)- (3)Fc Tag & Avi Tag (3)Mouse IgG Fc Tag (1)
マーカー
Unconjugated (13)Biotin-labeled (10)FITC Labeled (1)- (2)PE Labeled (1)

製品番号	種	発現システム	製品説明
HOT NE4-H52H3	Human	HEK293	Human Nectin-4 Protein, His Tag, low endotoxin (MALS verified)
HOT NE4-H82E7	Human	HEK293	Biotinylated Human Nectin-4 Protein, His,Avitag™ (MALS verified)
HOT NE4-M52H3	Mouse	HEK293	Mouse Nectin-4 Protein, His Tag (MALS & BLI verified)
HOT NE4-M82E7	Mouse	HEK293	Biotinylated Mouse Nectin-4 Protein, His,Avitag™ (MALS verified)
CHEK-ATP035	Human	HEK293	HEK293/Human Nectin-4 Stable Cell Line
MBS-K039	Human	-	Human Nectin-4-coupled Magnetic Beads
NE4-H5243	Human	HEK293	Human Nectin-4 (32-153) Protein, His Tag (MALS verified)
NE4-H5253	Human	HEK293	Human Nectin-4 Protein, Mouse IgG2a Fc Tag (MALS verified)
NE4-H5255	Human	HEK293	Human Nectin-4 Protein, Fc Tag, low endotoxin (MALS verified)
NE4-H52E3	Human	HEK293	Unconjugated Human Nectin-4 Protein, His,Avitag™ (MALS verified)

総数量27

お問い合わせ

Nectin-4バックグランド

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Nectin-4分子の別称

NECTIN4,LNIR, PRR4, PVRL4

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
SYS-6002	SYS-6002; SYS6002; CRB-701	Phase 3 Clinical	CSPC Pharmaceutical Group Ltd, Jushi Biopharmaceutical Co Ltd	Carcinoma, Transitional Cell; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	詳細
SHR-A2102	SHR-A2102	Phase 3 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Metastatic breast cancer; Neoplasms; Pancreatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
Bulumtatug fuvedotin	9MW2821; 9MW-2821; 9-MW2821; 9-MW-2821	Phase 3 Clinical	Mabwell (Shanghai) Bioscience Co Ltd	Carcinoma; Carcinoma, Transitional Cell; Genital Neoplasms, Female; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms	詳細
Zelenectide pevedotin	BT-8009	Phase 3 Clinical	Bicycle Tx Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	詳細
BT-7480	BT-7480	Phase 2 Clinical	Bicycle Therapeutics	Neoplasms; Solid tumours	詳細
VBC-103	AVZO-103; VAC-103; VBC-103; VBC103	Phase 2 Clinical	VelaVigo Cayman Ltd	Carcinoma; Carcinoma, Transitional Cell; Solid tumours; Triple Negative Breast Neoplasms	詳細
SC-101	SC-101	Phase 2 Clinical	Tianjin Conjustar Biotechnology Co Ltd	Breast Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	詳細
SKB-410	SKB410; SKB-410; MK-3120	Phase 2 Clinical	Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	Neoplasms; Solid tumours; Urinary Bladder Neoplasms	詳細
PSMA/NKG2DL/FAP-targeted Hi-TCR-T cells		Phase 1 Clinical	Shenzhen Misheng Biotechnology Co Ltd	Prostatic Neoplasms; Solid tumours	詳細
BA-3361	BA3361; BA-3361	Phase 1 Clinical	Bioatla	Neoplasms	詳細
ETx-22	ETx-22; LY4101174	Phase 1 Clinical	Emergence Therapeutics AG	Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Esophageal Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Pelvic Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
EB-DT-NK-UC101	EB-DT-NK-UC101	Phase 1 Clinical	Beijing Biotech	Carcinoma; Carcinoma, Transitional Cell; Urethral Neoplasms; Urinary Bladder Neoplasms	詳細
68Ga-Nectin-4		Phase 1 Clinical	The First Affiliated Hospital Of Soochow University	Solid tumours	詳細
[64Cu]Cu-AKY-1189	[64Cu]Cu-AKY-1189	Phase 1 Clinical	Aktis Oncology Inc	Neoplasms	詳細
AKY-1189	AKY-1189; [225Ac]Ac-AKY-1189; 225Ac-AKY-1189	Phase 1 Clinical	Aktis Oncology Inc	Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細
AK-146-D-1	AK146D1; AK-146-D1	Phase 1 Clinical		Solid tumours	詳細
Nectin-4 targeting antibody drug conjugate 2 (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	詳細
Nectin-4 targeting antibody drug conjugate 1 (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	詳細
XKDCT-293	XKDCT-293; XKDCT293	Phase 1 Clinical	Shenzhen Celconta Life Science Co Ltd	Breast Neoplasms	詳細
IPH-4502	IPH4502; IPH-4502	Phase 1 Clinical	Innate Pharma SA	Solid tumours	詳細
LY-4052031	LY-4052031	Phase 1 Clinical	Eli Lilly & Company Lilly France	Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Esophageal Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Pelvic Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
RNDO-564	RNDO-564	Phase 1 Clinical	Rondo Therapeutics	Carcinoma; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	詳細
ADRX-0706	ADRX-0706	Phase 1 Clinical	Adcentrx Therapeutics Inc	Carcinoma; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	詳細
BAT-8007	BAT-8007	Phase 1 Clinical	Bio-Thera Solutions Ltd	Solid tumours	詳細
Nectin-4 targeting radiopharmaceutical program (Aktis Oncology)		Clinical	Aktis Oncology Inc	Solid tumours	詳細
[68Ga]Ga-NOTA-RND20		Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Digestive System Neoplasms	詳細
[18F]F-RESCA-RND20		Clinical	Renji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine	Digestive System Neoplasms	詳細
CT-341	CT-341	Clinical	Shenzhen Celconta Life Science Co Ltd	Breast Neoplasms	詳細
68Ga-N188	68Ga-N188; 68-Ga-N-188	Clinical	Yunnan Baiyao Group Co Ltd	Carcinoma, Transitional Cell; Neoplasms	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Enfortumab vedotin	AGS-22C3E; AGS-22C3; ASG-22CE; AGS-M6; ASG-22M6E; DLE8519RWM; ASG-22ME; AGS-22ME; AGS-22M6E	Approved	Agensys Inc, Seagen Inc	Padcev, 备思复	United States	Carcinoma, Transitional Cell	Astellas Pharma Us Inc	2019-12-18	Carcinoma; Carcinoma in Situ; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Intestinal Neoplasms; Kidney Neoplasms; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms	詳細

レビュー

O***s2022-07-30
0評価
Biotinylated Human Nectin-4 (32-153) Protein, His,Avitag™ (MALS verified)
We used this for an important reagent in discovery campaigns. This was a great product! It came sooner than expected, which was awesome because we were able to easily make deadlines! It was also high quality. We didn't have any problems with it, so I am very happy with the quality of service and product. I will definitely buy again. Thank you very much.
1***82019-10-11
8評価
Human Nectin-4 Protein, His Tag, low endotoxin (MALS verified)
I Purchased this antigen for monoclonal antibody generation and antibody screening. The purity has been test by SDS-PAGE. It has a single band and no heterologous protein. It was used for antibody screening, and the screened antibody has a good affinity with the antigen.