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Neprilysin

Neprilysin 詳細

英語名	Neprilysin	市販薬剤の数	3
治験薬の数	8	ターゲットの別称	EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase
研究＆開発段階	Approved

英語名	Neprilysin
ターゲットの別称	EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase
市販薬剤の数	3
治験薬の数	8
研究＆開発段階	Approved

Neprilysin 製品リスト

属性
Protein (3)
製品ライブラリ
オンライン (3)
種
Human (3)
タグ
Fc Tag (1)Tag Free (1)His Tag (1)
マーカー
Unconjugated (3)

製品番号	種	発現システム	製品説明
MME-H521b	Human	HEK293	Human Neprilysin / MME / CD10 Protein, Tag Free (active enzyme)
MME-H5243	Human	HEK293	Human Neprilysin / MME / CD10 Protein, His Tag (active enzyme, MALS verified)
MME-H526a	Human	HEK293	Human Neprilysin / MME / CD10 Protein, Fc Tag

総数量3

Neprilysinバックグランド

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

Neprilysin分子の別称

MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Dexecadotril		Phase 3 Clinical	Bioprojet Pharma	Gastrointestinal Diseases	詳細
Sacubitril/Valsartan (Chong Kun Dang Pharmaceutical)	CKD-202A	Phase 3 Clinical	Chong Kun Dang Pharmaceutical Corp	Essential Hypertension	詳細
QR-12000	QR-12000	Phase 3 Clinical	Wuhan Createrna Science and Technology Co Ltd	Essential Hypertension; Hypertension	詳細
Debio-0827	PL-37; Debio-0827	Phase 2 Clinical	Pharmaleads	Pain	詳細
Sacubitril	AHU-377	Phase 2 Clinical	Novartis Pharma Ag	Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Diabetes Mellitus; Essential Hypertension; Heart Failure; Hypertension; Insulin Resistance; Metabolic Diseases	詳細
Anti-CD10 CAR T-cell therapy (Zhujiang Hospital/Nanfang Hospital)		Phase 1 Clinical	Southern Medical University Zhujing Hospital	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	詳細
Sacubitril Valsartan Sodium Extended-Relesae Tablets(Taizhou Overseas Pharma)		Phase 1 Clinical	Taizhou Overseas Pharmaceuticals Co Ltd	Heart Failure	詳細
Sacubitril/Allisartan Isoproxil/Amlodipine Besylate		Phase 1 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Essential Hypertension	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Sacubitril/Allisartan Isoproxil	AHU-377/EXP3174; S-086	Approved	Shenzhen Salubris Pharmaceuticals Co Ltd	信超妥	Mainland China	Essential Hypertension	Shenzhen Salubris Pharmaceuticals Co Ltd	2025-05-20	Essential Hypertension; Heart Failure; Hypertension	詳細
Sacubitril/Valsartan Sodium Hydrate	LCZ-696; LCZ-696A	Approved	Novartis Pharma Ag	ENTRESTO SPRINKLE, Enresuto, Enrest, Entresto, Neparvis, 诺欣妥, 科畅欣	United States	Heart Failure	Novartis Pharmaceuticals Corp	2015-07-07	Breast Neoplasms; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Coronavirus Disease 2019 (COVID-19); Erectile Dysfunction; Essential Hypertension; Heart Defects, Congenital; Heart Diseases; Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Hepatic Insufficiency; Hypertension; Lymphoma; Myocardial Infarction; Obesity; Peripheral Arterial Disease; Postmyocardial Infarction Syndrome; Renal Insufficiency; Renal Insufficiency, Chronic; Ventricular Dysfunction, Left	詳細
Racecadotril	Tiorfan; Hidrasec	Approved	Bioprojet Pharma		France	Diarrhea	Bioprojet Pharma	1993-03-23	Diarrhea; Diarrhea, Infantile; Sepsis	詳細