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Nkp46

Nkp46 Overview

English Name	Natural cytotoxicity triggering receptor 1	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	NK cell-activating receptor，NK-p46，Lymphocyte antigen 94 homolog，NKp46，hNKp46，Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46)，Natural killer cell p46-related protein，LY94，Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46)，CD335 Antigen，CD335
Highest Development Stage	Phase 2 Clinical

English Name	Natural cytotoxicity triggering receptor 1
Target Synonym	NK cell-activating receptor，NK-p46，Lymphocyte antigen 94 homolog，NKp46，hNKp46，Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46)，Natural killer cell p46-related protein，LY94，Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46)，CD335 Antigen，CD335
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

Nkp46 Product List

Product Category
Protein (17)Cell (2)Antibody (1)
Product Status
Launched (20)
Species
Human (13)Cynomolgus (3)Mouse (4)
Tag
Fc Tag (4)His Tag (7)Llama IgG Fc Tag (2)Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)- (2)Tag Free (1)
Conjugate
Unconjugated (10)Biotin-labeled (5)- (2)PE Labeled (1)FITC Labeled (1)AF488 Labeled (1)

Cat. No.	Species	Host	Product Description
HOT NC1-H52H4	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, His Tag, low endotoxin (MALS verified)
HOT NC1-H52H6	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, His Tag
HOT NK6-H82E2	Human	HEK293	Biotinylated Human NKp46 / NCR1 / CD335 Protein, His Tag, ultra sensitivity (primary amine labeling)
HOT NP6-H82H3	Human	HEK293	Biotinylated Human NKp46 / NCR1 / CD335 Protein, His,Avitag™, premium grade
CHEK-ATP153	Human	HEK293	HEK293/Human NKp46 Stable Cell Line
NC1-H5255	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin
NC1-H5257	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Fc Tag, premium grade
NC1-H5258	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Fc Tag
NC1-H5259	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Fc Tag
NC1-H82F9	Human	HEK293	Biotinylated Human NKp46 / NCR1 / CD335 Protein, Fc,Avitag™, premium grade

Total: 20

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Nkp46 Background

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Nkp46 Synonyms

Nkp46

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
NY-303	NY-303	Phase 2 Clinical	NAYA Biosciences Inc	Carcinoma, Hepatocellular; Solid tumours	Details
IPH-6501	IPH-6501; IPH-65	Phase 2 Clinical	Innate Pharma SA	Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms	Details
SAR-443579	SAR-443579; SAR443579; SAR'579; IPH6101; IPH-6101	Phase 1 Clinical	Sanofi	Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Diseases; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	Details