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NOTCH1

NOTCH1 Overview

English Name	Neurogenic locus notch homolog protein 1	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
Highest Development Stage	Phase 1 Clinical

English Name	Neurogenic locus notch homolog protein 1
Target Synonym	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

NOTCH1 Product List

Product Category
Protein (4)
Product Status
Launched (4)
Species
Mouse (1)Human (3)
Tag
His Tag (2)Fc Tag (2)
Conjugate
Unconjugated (3)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT NO1-H52H3	Human	HEK293	Human NOTCH1 Protein, His Tag, premium grade
NO1-H5255	Human	HEK293	Human NOTCH1 Protein, Fc Tag (MALS verified)
NO1-H8253	Human	HEK293	Biotinylated Human NOTCH1 Protein, Fc Tag, ultra sensitivity (primary amine labeling)
NO1-M52H8	Mouse	HEK293	Mouse NOTCH1 Protein, His Tag

Total: 4

NOTCH1 Background

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1 Synonyms

NOTCH1,Notch 1,hN1,TAN1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Crenigacestat	JSMD-194; LY-3039478; BMS-986405	Phase 1 Clinical	Eli Lilly And Company	Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Cholangiocarcinoma; Colonic Neoplasms; Leiomyosarcoma; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Lymphoma; Lymphoma, B-Cell; Lymphoma, T-Cell; Multiple Myeloma; Neoplasm Metastasis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms	Details