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Osteoactivin

Osteoactivin 詳細

英語名	Transmembrane glycoprotein NMB	市販薬剤の数	0
治験薬の数	2	ターゲットの別称	Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
研究＆開発段階	Phase 2 Clinical

英語名	Transmembrane glycoprotein NMB
ターゲットの別称	Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
市販薬剤の数	0
治験薬の数	2
研究＆開発段階	Phase 2 Clinical

Osteoactivin 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
GPB-H5229	Human	HEK293	Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin

総数量1

Osteoactivinバックグランド

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Osteoactivin分子の別称

GPNMB,HGFIN,NMB,Osteoactivin

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Glembatumumab vedotin	CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE	Phase 2 Clinical	Celldex Therapeutics	Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma; Osteosarcoma; Skin Melanoma; Solid tumours; Triple Negative Breast Neoplasms; Uveal melanoma	詳細
GPNMB-targeting Chimeric Antigen Receptor T-Cell Therapy (AHS Cancer Control Alberta)	GCAR1	Phase 1 Clinical	AHS Cancer Control Alberta	Carcinoma, Renal Cell; Sarcoma; Sarcoma, Alveolar Soft Part; Triple Negative Breast Neoplasms	詳細

レビュー

A***c2026-02-27
0評価
Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin
The Human Osteoactivin / GPNMB Protein, His Tag I purchased has been a reliable and useful reagent for interference testing. This reagent was optimal for work in both a PK and ADA assay. There have been no observed lot to lot differences, which is important in my line of work. I would recommend this product.