言語を選択
新規登録

Osteoprotegerin

Osteoprotegerin 詳細

英語名Tumor necrosis factor ligand superfamily member 11市販薬剤の数19
治験薬の数12ターゲットの別称Osteoclast differentiation factor，TRANCE，TNFSF11，TNF-related activation-induced cytokine，Tumor necrosis factor ligand superfamily member 11，CD254，TNF Superfamily Member 11，Osteoprotegerin Ligand，Receptor Activator Of Nuclear Factor Kappa B Ligand，Tumor Necrosis Factor Superfamily Member 11，ODF，RANKL，OPGL，CD254 Antigen，HRANKL2，TNLG6B，OPTB2，SOdf，RANK Ligand，Tumor Necrosis Factor (Ligand) Superfamily， Member 11，Receptor Activator Of Nuclear Factor Kappa-B Ligand，Tumor Necrosis Factor Ligand 6B
研究＆開発段階Approved
英語名Tumor necrosis factor ligand superfamily member 11
ターゲットの別称Osteoclast differentiation factor，TRANCE，TNFSF11，TNF-related activation-induced cytokine，Tumor necrosis factor ligand superfamily member 11，CD254，TNF Superfamily Member 11，Osteoprotegerin Ligand，Receptor Activator Of Nuclear Factor Kappa B Ligand，Tumor Necrosis Factor Superfamily Member 11，ODF，RANKL，OPGL，CD254 Antigen，HRANKL2，TNLG6B，OPTB2，SOdf，RANK Ligand，Tumor Necrosis Factor (Ligand) Superfamily， Member 11，Receptor Activator Of Nuclear Factor Kappa-B Ligand，Tumor Necrosis Factor Ligand 6B
市販薬剤の数19
治験薬の数12
研究＆開発段階Approved

Osteoprotegerin 製品リスト

  • 属性

    Protein (2)

  • 製品ライブラリ

    オンライン (2)

  • 種

    Human (2)

  • タグ

    Fc Tag (1)His Tag (1)

  • マーカー

    Unconjugated (2)

製品番号種発現システム製品説明タンパク質の構造純度特性
TNB-H5220
Human
HEK293
Human Osteoprotegerin / TNFRSF11B Protein, His Tag
TNB-H5259
Human
HEK293
Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag
総数量2
  • 1

Osteoprotegerinバックグランド

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Osteoprotegerin分子の別称

TNFRSF11B,OCIF,OPG,Osteoprotegerin

治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
Denosumab biosimilar(Shanghai Hansoh)HS-20090; HS-20090-2Phase 3 ClinicalJiangsu Hansoh Pharmaceutical Group Co Ltd, Shanghai Hansoh Biomedical Co LtdBone Diseases; Bone metastases; Giant Cell Tumor of Bone; Hypercalcemia; Multiple Myeloma; Neoplasms; Nutritional and Metabolic Diseases; Osteoporosis, Postmenopausal; Solid tumours
詳細
Recombinant human anti-RANKL momoclonal antibody (Qilu Pharmaceutical)Phase 3 ClinicalQilu Pharmaceutical Co LtdNeoplasms; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (GlycoNex)SPD8; SPD-8Phase 3 ClinicalGlyconex IncNeoplasms; Osteoporosis
詳細
Denosumab biosimilar (Hetero Biopharma)Phase 3 ClinicalHetero Biopharma LtdSolid tumours
詳細
Denosumab biosimilar(Curateq Biologics)BP-16Phase 3 ClinicalCuraTeQ Biologics Pvt LtdOsteoporosis, Postmenopausal
詳細
Recombinant anti-RANKL monoclonal antibody(Jiangsu Pacific-Meinuoke)Phase 3 ClinicalJiangsu Pacific Minok Biopharmaceutical Co., Ltd.Osteoporosis, Postmenopausal
詳細
SHR-2017SHR-2017; SHR2017Phase 2 ClinicalSuzhou Suncadia Biopharmaceuticals Co LtdBone metastases; Multiple Myeloma; Osteoporosis; Solid tumours
詳細
LZM-004LZM-004Phase 1 ClinicalLivzon(Group) Pharmaceutical FactoryBone metastases
詳細
Recombinant human anti-RANKL antibody (Innovent Biologics)IBI-307Phase 1 ClinicalOsteoporosis
詳細
GB-223GB-223; GB223Phase 1 ClinicalGenor Biopharma Co LtdBone metastases; Bone Neoplasms; Giant Cell Tumor of Bone; Osteoporosis, Postmenopausal; Solid tumours
詳細
Denosumab biosimilar (Kpc Pharmaceuticals)MV-088Phase 1 ClinicalKpc Pharmaceuticals IncOsteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Zhejiang Hisun)HS629Phase 1 ClinicalZhejiang Hisun Pharmaceutical Co LtdBone metastases; Solid tumours
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Denosumab biosimilar (Teva Pharmaceutical)TVB-009P; TVB-009ApprovedTeva Pharmaceutical Industries LtdPONLIMSI, DEGEVMAEUBone Resorption; Osteoporosis, Postmenopausal; Osteoporosis; Giant Cell Tumor of Bone; Neoplasms, Bone TissueTeva Gmbh2025-11-17Bone Neoplasms; Bone Resorption; Giant Cell Tumor of Bone; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Henlius)HLX14; HLX-14ApprovedBilprevda, BildyosUnited StatesHypercalcemia; Giant Cell Tumors; Bone metastases; Osteoporosis, PostmenopausalShanghai Henlius Biotech Inc2025-08-29Arthritis, Rheumatoid; Bone metastases; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Fractures, Bone; Giant Cell Tumor of Bone; Giant Cell Tumors; Glucocorticoid-induced osteoporosis; Hypercalcemia; Multiple Myeloma; Neoplasm Metastasis; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms
詳細
NarlumosbartJMT-103ApprovedShanghai Jmt-Bio Inc津立泰, 津立生Mainland ChinaGiant Cell Tumor of BoneShanghai Jmt-Bio Inc2023-09-05Bone Diseases; Bone metastases; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Hypercalcemia; Multiple Myeloma; Neoplasms; Osteoporosis; Osteoporosis, Postmenopausal; Solid tumours
詳細
Denosumab biosimilar (Mabwell)9-MW-0311; 9MW0321; 9-MW0321; 9MW-0321; 9-MW-0321; TK-006; MW-032; MW-031; 9MW0311; 9-MW0311; 9MW-0311ApprovedJiangsu T-Mab Bio-Pharmaceuticals Co Ltd迈利舒, 迈卫健, MAIWEIJIAN, MAILISHUMainland ChinaOsteoporosis, PostmenopausalJiangsu T-Mab Bio-Pharmaceuticals Co Ltd2023-03-28Bone metastases; Bone Neoplasms; Breast Neoplasms; Giant Cell Tumor of Bone; Osteoporosis; Osteoporosis, Postmenopausal; Solid tumours
詳細
Denosumab biosimilar (Qilu Pharma)QL-1206ApprovedQilu Pharmaceutical Co Ltd鲁可欣Mainland ChinaOsteoporosis, PostmenopausalQilu Pharmaceutical Co Ltd2023-09-28Bone metastases; Giant Cell Tumor of Bone; Osteoporosis, Postmenopausal; Solid tumours
詳細
Denosumab biosimilar (Boan Biopharma/Luye)LY-01011; BA-1102; BA-6101; LY-06006ApprovedShandong Boan Biotechnology Co Ltd博洛加, Boluojia, Boyoubei, 博优倍Mainland ChinaOsteoporosis, PostmenopausalShandong Boan Biotechnology Co Ltd2022-11-08Bone metastases; Bone Neoplasms; Giant Cell Tumor of Bone; Neoplasm Metastasis; Neoplasms; Osteoporosis; Osteoporosis, Postmenopausal; Solid tumours
詳細
Denosumab biosimilar (Accord Healthcare)ApprovedAccord Healthcare SluJubereq, OsvyrtiEUOsteoporosis; Neoplasms, Bone Tissue; Giant Cell Tumor of Bone; Bone Resorption; Osteoporosis, PostmenopausalAccord Healthcare Slu2025-05-26Bone metastases; Bone Resorption; Giant Cell Tumor of Bone; Hypercalcemia; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
DenosumabNSC-744010; AMG-162ApprovedAmgen IncProlia, Xgeva, Pralia, Ranmark, 普罗力EUOsteoporosis, PostmenopausalAmgen Europe Bv2010-05-26Anorexia Nervosa; Arthritis, Rheumatoid; Arthropathy, Neurogenic; Bone Cysts, Aneurysmal; Bone Diseases; Bone Diseases, Metabolic; Bone metastases; Bone Neoplasms; Breast Diseases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Squamous Cell; Cataract; Chondroblastoma; Colonic Neoplasms; Crohn Disease; Endocrine Gland Neoplasms; Feeding and Eating Disorders; Fibroma; Fibrous Dysplasia of Bone; Fractures, Bone; Giant Cell Tumor of Bone; Giant Cell Tumors; Glucocorticoid-induced osteoporosis; Granuloma, Giant Cell; Head and Neck Neoplasms; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypercalcemia; Kidney Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Metastatic breast cancer; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Osteoarthritis; Osteoarthritis, Knee; Osteoblastoma; Osteogenesis Imperfecta; Osteoporosis; Osteoporosis
詳細
Denosumab biosimilar(Enzene Biosciences)ENZ-215ApprovedEnzene Biosciences LtdOsqayEUBone ResorptionTheramex Ireland Ltd2026-01-08Bone Resorption; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Alvotech Swiss)AVT-03; AVT03ApprovedAlvotech Swiss AgAcvybra, XbonzyEUGiant Cell Tumor of Bone; Osteoporosis, Postmenopausal; Bone Resorption; Neoplasms, Bone Tissue; OsteoporosisStada Arzneimittel Ag, Reddy Holding Gmbh2025-11-17Bone Resorption; Giant Cell Tumor of Bone; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar(Mabxience)MB-09ApprovedMabxience SaZadenvi, Izamby, Enwylma, DenbrayceEUNeoplasms, Bone Tissue; Bone Resorption; Osteoporosis, Postmenopausal; Osteoporosis; Giant Cell Tumor of BoneZentiva Ks, Mabxience Research SL2025-06-26Bone Diseases; Bone Resorption; Fractures, Bone; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Hypercalcemia; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Biocon Biologics)Bmab-1000ApprovedBiocon LtdVevzuo, EvfraxyEUNeoplasms, Bone Tissue; Giant Cell Tumor of BoneBiosimilar Collaborations Ireland Ltd2025-06-25Bone metastases; Bone Resorption; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms
詳細
Denosumab biosimilar(Reliance Life Sciences)R-TPR-045ApprovedReliance Life SciencesDenosuRelIndiaOsteoporosis, Postmenopausal; Bone metastasesReliance Life Sciences2022-02-01Bone metastases; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Gedeon Richter)RGB-14-PApprovedGedeon Richter PlcENOBY, XTRENBO, Yaxwer, JunodEUBone Resorption; Osteoporosis, Postmenopausal; Osteoporosis; Giant Cell Tumor of Bone; Neoplasms, Bone TissueGedeon Richter Plc2025-06-23Bone metastases; Bone Resorption; Breast Neoplasms; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms
詳細
Denosumab biosimilar(Fresenius Kabi)FKS-518ApprovedFresenius Kabi Swissbiosim GmbhBOMYNTRA, CONEXXENCEUnited StatesGiant Cell Tumor of Bone; Hypercalcemia; Bone metastasesFresenius Kabi Usa Llc2025-03-25Bone metastases; Bone Resorption; Giant Cell Tumor of Bone; Hypercalcemia; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Samsung Bioepis)SB-16ApprovedSamsung Bioepis Co LtdOspomyv, Xbryk, XBRYK, OBODENCEEUNeoplasms, Bone Tissue; Giant Cell Tumor of Bone; Bone Resorption; Osteoporosis; Osteoporosis, PostmenopausalSamsung Bioepis Nl Bv2025-02-12Bone Resorption; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Celltrion)CT-P41ApprovedCelltrion IncStoboclo, OsenveltEUBone Resorption; Osteoporosis, Postmenopausal; Osteoporosis; Neoplasms, Bone Tissue; Giant Cell Tumor of BoneCelltrion Healthcare Hungary Kft2025-02-14Bone Resorption; Breast Neoplasms; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms
詳細
Denosumab biosimilar (Sandoz)GP-2411ApprovedNovartis Pharma Ag, SandozJubbonti®, Wyost®United StatesOsteoporosis, Postmenopausal; Osteoporosis; Glucocorticoid-induced osteoporosisSandoz, Sandoz Inc2024-03-05Bone Resorption; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
詳細
Denosumab biosimilar (Alphamab)KN-012ApprovedSuzhou Alphamab Co LtdMainland ChinaOsteoporosis, PostmenopausalPhilippine Biological Technology (Jilin) ​​Co Ltd, Alphamab Jilin Co Ltd2024-09-03Osteoporosis, Postmenopausal
詳細
  • 詳細
  • 製品リスト
  • 市販薬剤に関する情報
  • 治験薬に関する情報
共有：

採用情報法的規制サイトマッププライバシーポリシー利用規約
ウェブサイトに関するフィードバック
お問い合わせ

お問い合わせ
グローバル：+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8