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OX40 Ligand

OX40 Ligand 詳細

英語名	Tumor necrosis factor ligand superfamily member 4	市販薬剤の数	0
治験薬の数	13	ターゲットの別称	CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Necrosis Factor Ligand 2B，OX40 Antigen Ligand
研究＆開発段階	Phase 3 Clinical

英語名	Tumor necrosis factor ligand superfamily member 4
ターゲットの別称	CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Necrosis Factor Ligand 2B，OX40 Antigen Ligand
市販薬剤の数	0
治験薬の数	13
研究＆開発段階	Phase 3 Clinical

OX40 Ligand 製品リスト

属性
Protein (17)Cell (1)
製品ライブラリ
オンライン (18)
種
Human (8)Mouse (4)Cynomolgus / Rhesus macaque (3)Rabbit (1)Rat (1)Canine (1)
タグ
His Tag (8)Mouse IgG Fc Tag (2)Avi Tag & Fc Tag (2)Fc Tag (2)His Tag & Avi Tag (3)- (1)
マーカー
Unconjugated (12)Biotin-labeled (5)- (1)

製品番号	種	発現システム	製品説明
HOT OXL-H5243	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, His Tag, active trimer, low endotoxin (MALS verified)
HOT OXL-H5266	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, Fc Tag, premium grade
HOT OXL-H52Q8	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, His Tag, active trimer, low endotoxin (MALS verified)
HOT OXL-H82Q5	Human	HEK293	Biotinylated Human OX40 Ligand / TNFSF4 Protein, His,Avitag™, active trimer (MALS verified)
CHEK-ATP054	Human	HEK293	HEK293/Human OX40 Ligand Stable Cell Line
OXL-H5250	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag, low endotoxin
OXL-H82F4	Human	HEK293	Biotinylated Human OX40 Ligand / TNFSF4 Protein, Avitag™,Fc Tag
OXL-H82F5	Human	HEK293	Biotinylated Human OX40 Ligand / TNFSF4 Protein, Fc,Avitag™, premium grade
OXL-M5243	Mouse	HEK293	Mouse OX40 Ligand / TNFSF4 Protein, His Tag, active trimer, low endotoxin (MALS verified)
OXL-M5263	Mouse	HEK293	Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag, active trimer, low endotoxin (MALS verified)

総数量18

OX40 Ligandバックグランド

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

OX40 Ligand分子の別称

OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Amlitelimab	KY-1005; SAR-445229	Phase 3 Clinical	Kymab Ltd, Sanofi	Alopecia Areata; Asthma; Celiac Disease; Dermatitis, Atopic; Eczema; Hidradenitis; Immune System Diseases; Lung Diseases, Interstitial; Scleroderma, Systemic	詳細
APG-279	APG279; APG-990/APG777	Phase 2 Clinical	Apogee Therapeutics Inc	Dermatitis, Atopic	詳細
IMB-101 (IMBiologics)	IMB-101 (IMBiologics); HDM-3019; IMB101 (IMBiologics); HDM3019; NAV-240	Phase 2 Clinical	IMBiologics Corp	Arthritis, Rheumatoid; Hidradenitis Suppurativa	詳細
IBI356	IBI-356; IBI356	Phase 2 Clinical		Autoimmune Diseases; Dermatitis, Atopic	詳細
RP-3	RP-3	Phase 2 Clinical	Replimune Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
HS-130	HS-130	Phase 1 Clinical	Heat Biologics	Solid tumours	詳細
mRNA-2752	mRNA-2752	Phase 1 Clinical	Astrazeneca Plc, Moderna Inc	Lymphoma; Neoplasms; Solid tumours	詳細
MQ-710	MQ-710	Phase 1 Clinical	Imvaq Therapeutics Corp, Memorial Sloan Kettering Cancer Center	Adenocarcinoma, Sebaceous; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Hemangiosarcoma; Melanoma; Neoplasm Metastasis; Neoplasms; Paget Disease, Extramammary; Sarcoma, Kaposi; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細
OX-118	OX-118	Phase 1 Clinical	Oxion Biologics AB	Autoimmune Diseases; Immune System Diseases; Rheumatic Diseases	詳細
M-5542	M5542; M-5542	Phase 1 Clinical	Merck & Co Inc		詳細
ABCL-575	ABCL-575; ABCL575	Phase 1 Clinical	AbCellera Biologics Inc	Dermatitis, Atopic	詳細
APG-990	APG-990; APG990; PR-007; PR007	Phase 1 Clinical	Paragon Therapeutics Inc	Dermatitis, Atopic	詳細
SAR-443726	SAR-443726	Phase 1 Clinical	Sanofi	Dermatitis, Atopic	詳細