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PTK7

PTK7 詳細

英語名	Protein-tyrosine kinase 7	市販薬剤の数	0
治験薬の数	8	ターゲットの別称	Colon carcinoma kinase 4，Inactive tyrosine-protein kinase 7，Tyrosine-protein kinase-like 7，CCK-4，PTK7，Protein Tyrosine Kinase 7 (Inactive)，Pseudo Tyrosine Kinase Receptor 7，PTK7 Protein Tyrosine Kinase 7，CCK4，Protein-Tyrosine Kinase 7，Protein Tyrosine Kinase 7
研究＆開発段階	Phase 2 Clinical

英語名	Protein-tyrosine kinase 7
ターゲットの別称	Colon carcinoma kinase 4，Inactive tyrosine-protein kinase 7，Tyrosine-protein kinase-like 7，CCK-4，PTK7，Protein Tyrosine Kinase 7 (Inactive)，Pseudo Tyrosine Kinase Receptor 7，PTK7 Protein Tyrosine Kinase 7，CCK4，Protein-Tyrosine Kinase 7，Protein Tyrosine Kinase 7
市販薬剤の数	0
治験薬の数	8
研究＆開発段階	Phase 2 Clinical

PTK7 製品リスト

属性
Protein (11)Cell (1)Antibody (1)
製品ライブラリ
オンライン (13)
種
Human (5)Mouse (3)Rabbit (2)Cynomolgus / Rhesus macaque (1)Rat (2)
タグ
His Tag (5)His Tag & Avi Tag (2)Fc Tag (3)Fc Tag & Avi Tag (1)- (2)
マーカー
Unconjugated (9)Biotin-labeled (3)- (1)

製品番号	種	発現システム	製品説明
HOT PT7-H5253	Human	HEK293	Human PTK7 / CCK4 Protein, Fc Tag (MALS verified)
HOT PT7-H52H3	Human	HEK293	Human PTK7 / CCK4 Protein, His Tag, low endotoxin (MALS verified)
HOT PT7-H82E5	Human	HEK293	Biotinylated Human PTK7 / CCK4 protein, His,Avitag™ (MALS verified)
HOT PT7-M52H3	Mouse	HEK293	Mouse PTK7 / CCK4 Protein, His Tag (MALS verified)
HOT PT7-C52H3	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque PTK7 / CCK4 Protein, His Tag (MALS verified)
CHEK-ATP186	Human	HEK293	HEK293/Human PTK7 Stable Cell Line
PT7-H82F5	Human	HEK293	Biotinylated Human PTK7 / CCK4 protein, Fc,Avitag™ (MALS verified)
PT7-M5256	Mouse	HEK293	Mouse PTK7 / CCK4 Protein, Fc Tag (MALS verified)
PT7-M82E3	Mouse	HEK293	Biotinylated Mouse PTK7 / CCK4 Protein, His,Avitag™ (MALS verified)
HGS-M2715	Rabbit	-	Recombinant Monoclonal Anti-PTK7 Antibody, Rabbit (P2A01)

総数量13

PTK7バックグランド

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

PTK7分子の別称

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
SKB-518	SKB518; SKB-518	Phase 2 Clinical	Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	Genital Neoplasms, Female; Lung Neoplasms; Neoplasms; Solid tumours	詳細
Cofetuzumab Pelidotin	PF-06647020; PF-6647020; PTK7-ADC; PF-06523435; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101	Phase 1 Clinical	Abbvie Inc, Stemcentrx Inc	Carcinoma, Non-Small-Cell Lung; Neoplasms	詳細
68Ga-Sgc8		Phase 1 Clinical	The First Affiliated Hospital of Air Force Medical University	Colorectal Neoplasms	詳細
PTK7 ADC (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	詳細
KIVU-107	KIVU-107	Phase 1 Clinical	Kivu Bioscience Inc	Solid tumours	詳細
LY-4175408	LY4175408; LY-4175408	Phase 1 Clinical	Eli Lilly And Company	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasm Metastasis; Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms	詳細
IDE-034	BCG034; IDE034; IDE-034	Phase 1 Clinical		Colorectal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Solid tumours	詳細
DAY-301	DAY301; DAY-301; MTX-13; CB-002	Phase 1 Clinical	Shanghai Mycos Biomedicine Co Ltd	Solid tumours	詳細

レビュー

1***62022-08-09
0評価
Human PTK7 / CCK4 Protein, His Tag, low endotoxin (MALS verified)
Validated by SPR, measured monovalent affinity, anti-human FC chip, loaded diluted antibody, added diluted Folate R, His tag, with the affinity constant of 4 nM.