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PTK7

PTK7 Overview

English Name	Protein-tyrosine kinase 7	Approved Drugs	0
Drugs in Clinical Trials	8	Target Synonym	Colon carcinoma kinase 4，Inactive tyrosine-protein kinase 7，Tyrosine-protein kinase-like 7，CCK-4，PTK7，Protein Tyrosine Kinase 7 (Inactive)，Pseudo Tyrosine Kinase Receptor 7，PTK7 Protein Tyrosine Kinase 7，CCK4，Protein-Tyrosine Kinase 7，Protein Tyrosine Kinase 7
Highest Development Stage	Phase 2 Clinical

English Name	Protein-tyrosine kinase 7
Target Synonym	Colon carcinoma kinase 4，Inactive tyrosine-protein kinase 7，Tyrosine-protein kinase-like 7，CCK-4，PTK7，Protein Tyrosine Kinase 7 (Inactive)，Pseudo Tyrosine Kinase Receptor 7，PTK7 Protein Tyrosine Kinase 7，CCK4，Protein-Tyrosine Kinase 7，Protein Tyrosine Kinase 7
Approved Drugs	0
Drugs in Clinical Trials	8
Highest Development Stage	Phase 2 Clinical

PTK7 Product List

Product Category
Protein (11)Cell (1)Antibody (1)
Product Status
Launched (13)
Species
Human (5)Mouse (3)Rabbit (2)Cynomolgus / Rhesus macaque (1)Rat (2)
Tag
His Tag (5)His Tag & Avi Tag (2)Fc Tag (3)Fc Tag & Avi Tag (1)- (2)
Conjugate
Unconjugated (9)Biotin-labeled (3)- (1)

Cat. No.	Species	Host	Product Description
HOT PT7-H5253	Human	HEK293	Human PTK7 / CCK4 Protein, Fc Tag (MALS verified)
HOT PT7-H52H3	Human	HEK293	Human PTK7 / CCK4 Protein, His Tag, low endotoxin (MALS verified)
HOT PT7-H82E5	Human	HEK293	Biotinylated Human PTK7 / CCK4 protein, His,Avitag™ (MALS verified)
HOT PT7-M52H3	Mouse	HEK293	Mouse PTK7 / CCK4 Protein, His Tag (MALS verified)
HOT PT7-C52H3	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque PTK7 / CCK4 Protein, His Tag (MALS verified)
CHEK-ATP186	Human	HEK293	HEK293/Human PTK7 Stable Cell Line
PT7-H82F5	Human	HEK293	Biotinylated Human PTK7 / CCK4 protein, Fc,Avitag™ (MALS verified)
PT7-M5256	Mouse	HEK293	Mouse PTK7 / CCK4 Protein, Fc Tag (MALS verified)
PT7-M82E3	Mouse	HEK293	Biotinylated Mouse PTK7 / CCK4 Protein, His,Avitag™ (MALS verified)
HGS-M2715	Rabbit	-	Recombinant Monoclonal Anti-PTK7 Antibody, Rabbit (P2A01)

Total: 13

PTK7 Background

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

PTK7 Synonyms

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
SKB-518	SKB518; SKB-518	Phase 2 Clinical	Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	Genital Neoplasms, Female; Lung Neoplasms; Neoplasms; Solid tumours	Details
Cofetuzumab Pelidotin	PF-06647020; PF-6647020; PTK7-ADC; PF-06523435; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101	Phase 1 Clinical	Abbvie Inc, Stemcentrx Inc	Carcinoma, Non-Small-Cell Lung; Neoplasms	Details
68Ga-Sgc8		Phase 1 Clinical	The First Affiliated Hospital of Air Force Medical University	Colorectal Neoplasms	Details
PTK7 ADC (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	Details
KIVU-107	KIVU-107	Phase 1 Clinical	Kivu Bioscience Inc	Solid tumours	Details
LY-4175408	LY4175408; LY-4175408	Phase 1 Clinical	Eli Lilly And Company	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasm Metastasis; Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms	Details
IDE-034	BCG034; IDE034; IDE-034	Phase 1 Clinical		Colorectal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Solid tumours	Details
DAY-301	DAY301; DAY-301; MTX-13; CB-002	Phase 1 Clinical	Shanghai Mycos Biomedicine Co Ltd	Solid tumours	Details

Product Reviews

1***62022-08-09
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Human PTK7 / CCK4 Protein, His Tag, low endotoxin (MALS verified)
Validated by SPR, measured monovalent affinity, anti-human FC chip, loaded diluted antibody, added diluted Folate R, His tag, with the affinity constant of 4 nM.