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R-Spondin 3

R-Spondin 3 詳細

英語名	R-spondin-3	市販薬剤の数	0
治験薬の数	0	ターゲットの別称	Thrombospondin Type-1 Domain-Containing Protein 2，Thrombospondin， Type I， Domain Containing 2，Protein With TSP Type-1 Repeat，PWTSR，R-Spondin 3 Homolog (Xenopus Laevis)，R-Spondin 3 Homolog，R-Spondin-3，CRISTIN1，HRspo3，FLJ14440，Roof plate-specific spondin-3，RSPO3，hPWTSR，THSD2，R-Spondin 3
研究＆開発段階	Preclinical

英語名	R-spondin-3
ターゲットの別称	Thrombospondin Type-1 Domain-Containing Protein 2，Thrombospondin， Type I， Domain Containing 2，Protein With TSP Type-1 Repeat，PWTSR，R-Spondin 3 Homolog (Xenopus Laevis)，R-Spondin 3 Homolog，R-Spondin-3，CRISTIN1，HRspo3，FLJ14440，Roof plate-specific spondin-3，RSPO3，hPWTSR，THSD2，R-Spondin 3
市販薬剤の数	0
治験薬の数	0
研究＆開発段階	Preclinical

R-Spondin 3 製品リスト

属性
Protein (2)
製品ライブラリ
オンライン (2)
種
Human (2)
タグ
His Tag (1)Fc Tag (1)
マーカー
Unconjugated (2)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
RS3-H5253	Human	HEK293	Human R-Spondin 3 / RSPO3 Protein, Fc Tag
RS6-H5222	Human	HEK293	Human R-Spondin 3 / RSPO3 (22-146) Protein, His Tag

総数量2

R-Spondin 3バックグランド

R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.