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ROR1

ROR1 詳細

英語名	Inactive tyrosine-protein kinase transmembrane receptor ROR1	市販薬剤の数	0
治験薬の数	23	ターゲットの別称	EC 2.7.10.1，Inactive tyrosine-protein kinase transmembrane receptor ROR1，NTRKR1，ROR1，Receptor Tyrosine Kinase Like Orphan Receptor 1，Neurotrophic Tyrosine Kinase， Receptor-Related 1，DJ537F10.1，ROR-1
研究＆開発段階	Phase 3 Clinical

英語名	Inactive tyrosine-protein kinase transmembrane receptor ROR1
ターゲットの別称	EC 2.7.10.1，Inactive tyrosine-protein kinase transmembrane receptor ROR1，NTRKR1，ROR1，Receptor Tyrosine Kinase Like Orphan Receptor 1，Neurotrophic Tyrosine Kinase， Receptor-Related 1，DJ537F10.1，ROR-1
市販薬剤の数	0
治験薬の数	23
研究＆開発段階	Phase 3 Clinical

ROR1 製品リスト

属性
Protein (20)Beads (1)Cell (1)
製品ライブラリ
オンライン (22)
種
Human / Cynomolgus / Rhesus macaque (9)Mouse (4)Rat (1)Human (8)
タグ
Fc Tag (3)His Tag (11)Fc Tag & Avi Tag (2)Avi Tag (1)His Tag & Avi Tag (2)- (2)Mouse IgG Fc Tag (1)
マーカー
Unconjugated (10)Biotin-labeled (5)- (2)FITC Labeled (2)PE Labeled (2)APC Labeled (1)

製品番号	種	発現システム	製品説明
HOT RO1-HA2H4	Human	HEK293	APC-Labeled Human ROR1 Protein, His TagStar Staining
HOT RO1-HP2E3	Human	HEK293	PE-Labeled Human ROR1 Protein, His Tag (Site-specific conjugation)
HOT RO1-H5223	Human / Cynomolgus / Rhesus macaque	HEK293	Human / Cynomolgus / Rhesus macaque ROR1 (308-395, Kringle domain) Protein, His Tag (MALS verified)
HOT RO1-H522y	Human / Cynomolgus / Rhesus macaque	HEK293	Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag, low endotoxin (MALS verified)
HOT RO1-H82E6	Human / Cynomolgus / Rhesus macaque	HEK293	Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, His,Avitag™ (MALS verified)
CHEK-ATP084	Human	HEK293	HEK293/Human ROR1 Stable Cell Line
MBR-K009	Human	-	Human ROR1-coupled Magnetic Beads
RO1-H52H3	Human	HEK293	Human ROR1 (30-305) Protein, His Tag (MALS verified)
RO1-HF253	Human	HEK293	FITC-Labeled Human ROR1 Protein, Fc Tag
RO1-HF258	Human	HEK293	FITC-Labeled Human ROR1 Protein, His Tag

総数量22

ROR1バックグランド

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

ROR1分子の別称

ROR1,NTRKR1

抗体購入プラットフォーム

プロジェクト	ステージ	タイプ	由来	疾患領域	適応症
ROR1 mAb - 01	Lead	Monoclonal	Full Human	Hematological Malignancy,AutoImmunity	Solid tumor,Blood tumor

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Zilovertamab vedotin	MK-2140; VLS-101	Phase 3 Clinical	Velosbio Inc	Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Richter's Syndrome; Sarcoma, Ewing; Stomach Neoplasms; Triple Negative Breast Neoplasms; Waldenstrom Macroglobulinemia	詳細
B-013	B-013; B013	Phase 3 Clinical	Shanghai Crosslink Pharmaceutical R & D Co Ltd	Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Triple Negative Breast Neoplasms	詳細
Zilovertamab	UC-961	Phase 2 Clinical	University Of California San Diego	Breast Neoplasms; Immune System Diseases; Immunoproliferative Disorders; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphatic Diseases; Lymphoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Prostatic Neoplasms, Castration-Resistant	詳細
EMB-07	EMB-07	Phase 2 Clinical	Shanghai Epimab Biotherapeutics, Inc	Adenocarcinoma of Lung; Colorectal Neoplasms; Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms	詳細
EB-DT-CAR-NK	EB-DT-CAR-NK	Phase 2 Clinical	Beijing Biotech	Breast Neoplasms; Triple Negative Breast Neoplasms	詳細
NVG-222	NVG-222	Phase 2 Clinical	NovalGen Ltd	Hematologic Neoplasms; Neoplasms	詳細
HDM-2005	HDM2005; HDM-2005	Phase 2 Clinical	Hangzhou Zhongmei Huadong Pharmaceutical Co Ltd	Hematologic Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Neoplasms; Solid tumours	詳細
Nebratamig	GNC-035	Phase 2 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Breast Neoplasms; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Metastatic breast cancer; Solid tumours	詳細
HG-030	HG-030	Phase 1 Clinical	Hitgen Inc	Solid tumours	詳細
anti-ROR1 CAR T-cell therapy (Fred Hutchinson Cancer Research Center/NCI)		Phase 1 Clinical	National Cancer Institute	Neoplasms	詳細
PB-004	PB004; PBA-0405; PB004 PureBIKE; PB-004	Phase 1 Clinical	Pure Biologics SA	Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	詳細
PRGN-3007	PRGN-3007	Phase 1 Clinical	Precigen Inc	Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Triple Negative Breast Neoplasms	詳細
RD-14	RD-14; RD-14-01; CTE001; RD14-01	Phase 1 Clinical	Nanjing Bioheng Biotech Co Ltd	Breast Neoplasms; Lymphoma, Non-Hodgkin; Ovarian Neoplasms	詳細
NEOK-001	NEOK001; NEOK-001; ABL206; ABL-206	Phase 1 Clinical	Abl Bio Inc	Solid tumours	詳細
BR-111	BR-111	Phase 1 Clinical	Zhejiang BioRay Biopharmaceuticals Co Ltd	Neoplasms	詳細
SYS-6005	RB-164; RB164; SYS6005Y; SYS-6005	Phase 1 Clinical	CSPC Pharmaceutical Group Ltd	Hematologic Neoplasms; Leukemia, B-Cell; Lymphoma, B-Cell; Neoplasms; Solid tumours	詳細
TQB-2101	TQB2101; TQB-2101	Phase 1 Clinical	Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group	Breast Neoplasms; Colorectal Neoplasms; Hematologic Neoplasms; Lung Neoplasms; Neoplasms	詳細
ZPC-21	ZPC-21; IM-1021	Phase 1 Clinical	Zentalis Pharmaceuticals Inc	Hematologic Neoplasms; Neoplasms; Solid tumours	詳細
BR-111A	BR-111A; BR111A; BR-111-A	Phase 1 Clinical	Zhejiang BioRay Biopharmaceuticals Co Ltd	Hematologic Diseases; Neoplasms; Solid tumours	詳細
LYL-797	LYL-797	Phase 1 Clinical	Lyell Immunopharma Inc	Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms	詳細
NVG-111	NVG-111	Phase 1 Clinical	NovalGen Ltd	Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Melanoma	詳細
LCB-71	CS-5001; LCB-71; ABL-202; ROR1-pPBD	Phase 1 Clinical	Abl Bio Inc, Legochem Biosciences Inc	Hematologic Neoplasms; Lymphoma; Lymphoma, B-Cell; Solid tumours	詳細
SIM-201	SIM-201; SIM-0201	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd	Solid tumours	詳細