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SDF-1

SDF-1 詳細

英語名	C-X-C motif chemokine ligand 12	市販薬剤の数	0
治験薬の数	5	ターゲットの別称	Pre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A
研究＆開発段階	Phase 2 Clinical

英語名	C-X-C motif chemokine ligand 12
ターゲットの別称	Pre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A
市販薬剤の数	0
治験薬の数	5
研究＆開発段階	Phase 2 Clinical

SDF-1 製品リスト

属性
Protein (4)
製品ライブラリ
オンライン (3)研究中 (1)
種
Human (4)
タグ
His Tag (1)Tag Free (3)
マーカー
Unconjugated (4)

製品番号	種	発現システム	製品説明
GMP-SD1H13	Human	E. coli	GMP Human SDF-1 / CXCL12 Protein
SD1-H5115	Human	E. coli	Human SDF-1 / CXCL12 Protein, premium grade
SD1-H5116	Human	E. coli	Human SDF-1 / CXCL12 Protein, Research Grade
SD1-H5143	Human	E. coli	Human SDF-1 / CXCL12 Protein, His Tag (HPLC & SPR verified)

総数量4

SDF-1バックグランド

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells

SDF-1分子の別称

SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Olaptesed Pegol	NOX-A12	Phase 2 Clinical	Noxxon Pharma	Colorectal Neoplasms; Glioblastoma; Hematopoietic stem cell transplantation (HSCT); Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Pancreatic Neoplasms	詳細
PTX-9908	PTX-9908	Phase 2 Clinical	Pertinax Therapeutics	Carcinoma, Hepatocellular	詳細
JVS-100	JVS-100; SRX-100; ACRX-100; GP-51801; GP51801	Phase 1 Clinical	Cleveland Clinic	Heart Failure; Ischemia; Peripheral Arterial Disease; Surgical Wound	詳細
CK-0804	CK-08041; CK-0804	Phase 1 Clinical	Cellenkos Inc	Primary Myelofibrosis	詳細
MyoCell SDF-1	MyoCell SDF-1	Clinical	U.S. Stem Cell	Heart Failure	詳細