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Semaphorin 4D

Semaphorin 4D 詳細

英語名	Semaphorin 4D	市販薬剤の数	0
治験薬の数	1	ターゲットの別称	SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D
研究＆開発段階	Phase 2 Clinical

英語名	Semaphorin 4D
ターゲットの別称	SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D
市販薬剤の数	0
治験薬の数	1
研究＆開発段階	Phase 2 Clinical

Semaphorin 4D 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
Fc Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
CD0-H5257	Human	HEK293	Human Semaphorin 4D / SEMA4D / CD100 Protein, Fc Tag

総数量1

Semaphorin 4Dバックグランド

Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

Semaphorin 4D分子の別称

SEMA4D,C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4,Semaphorin-4D

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Pepinemab	VX-15; VX-15/2503; moAb VX-15/2503	Phase 2 Clinical	Vaccinex Inc	Alzheimer Disease; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Huntington Disease; Melanoma; Multiple Sclerosis; Osteosarcoma; Pancreatic Neoplasms; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	詳細