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Serpin A1

Serpin A1 詳細

英語名	Alpha-1-antiproteinase	市販薬剤の数	2
治験薬の数	14	ターゲットの別称	Alpha-1-antiproteinase，PRO2209，Serpin Family A Member 1，alpha 1-Antitrypsin，Protease Inhibitor 1 (Anti-Elastase)， Alpha-1-Antitrypsin，Alpha-1 Protease Inhibitor，Serpin A1，AAT，PI，Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase， Antitrypsin) Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C4，Serpin Peptidase Inhibitor Clade A Member 1，Alpha-1-Antitrypsin Null，Alpha-1 Antitrypsin，Alpha-1-Antitrypsin，Alpha1AT，PRO2275，NNIF，A1A，PI1，Epididymis Secretory Sperm Binding Protein，Serpin Peptidase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C5，A1AT，PRO0684，SPAAT，SERPINA1
研究＆開発段階	Approved

英語名	Alpha-1-antiproteinase
ターゲットの別称	Alpha-1-antiproteinase，PRO2209，Serpin Family A Member 1，alpha 1-Antitrypsin，Protease Inhibitor 1 (Anti-Elastase)， Alpha-1-Antitrypsin，Alpha-1 Protease Inhibitor，Serpin A1，AAT，PI，Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase， Antitrypsin) Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C4，Serpin Peptidase Inhibitor Clade A Member 1，Alpha-1-Antitrypsin Null，Alpha-1 Antitrypsin，Alpha-1-Antitrypsin，Alpha1AT，PRO2275，NNIF，A1A，PI1，Epididymis Secretory Sperm Binding Protein，Serpin Peptidase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C5，A1AT，PRO0684，SPAAT，SERPINA1
市販薬剤の数	2
治験薬の数	14
研究＆開発段階	Approved

Serpin A1 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag (1)
マーカー
Unconjugated (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
SE1-H5226	Human	HEK293	Human Serpin A1 Protein, His Tag

総数量1

Serpin A1バックグランド

Serpin A1 is also known as Alpha-1-antitrypsin (A1AT), serum trypsin inhibitor, alpha-1 proteinase inhibitor (A1PI), AAT, which belongs to the serpin family. Most serpins inactivate enzymes by binding to them covalently, requiring very high levels to perform their function. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Serpin A1 / A1AT is inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form of SerpinA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Serpin A1 / A1AT protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD).

Serpin A1分子の別称

SerpinA1,PI,A1A,AAT,PI1,A1AT,MGC9222,PRO2275,MGC23330,alpha1AT,SPAAT

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Fazirsiran	TAK-999; ADS-001; ARO-AAT	Phase 3 Clinical	Arrowhead Pharmaceuticals Inc, Takeda Pharmaceutical Co Ltd	alpha 1-Antitrypsin Deficiency; Hepatic Insufficiency	詳細
YOLT-202	YOLT-202	Phase 3 Clinical	Shanghai Yaotang Biotechnology Co Ltd	alpha 1-Antitrypsin Deficiency; Genetic Diseases, Inborn	詳細
Efdoralprin alfa	INBRX-101; AT-292; rhAAT-Fc; AAT-IgG-Fc; AAT-Fc; SAR447537; SAR-447537	Phase 2 Clinical	Arecor Ltd, Inhibrx	alpha 1-Antitrypsin Deficiency; Emphysema	詳細
TSRA-196	TSRA-196	Phase 2 Clinical	Tessera Therapeutics Inc	alpha 1-Antitrypsin Deficiency	詳細
VX-864	VX-864	Phase 2 Clinical	Vertex Pharmaceuticals Incorporated	alpha 1-Antitrypsin Deficiency	詳細
KRRO-110	KRRO-110	Phase 2 Clinical	Korro Bio Inc	alpha 1-Antitrypsin Deficiency	詳細
WVE-006	WVE-006; GSK-5462688	Phase 2 Clinical	Wave Life Sciences Ltd	alpha 1-Antitrypsin Deficiency	詳細
BEAM-302	α1-AD; α-1-AD; BEAM-302	Phase 2 Clinical	Beam Therapeutics Inc	alpha 1-Antitrypsin Deficiency	詳細
adeno-associated virus gene therapy (University of Massachusetts/University of Florida/NHLBI)		Phase 1 Clinical	University of Massachusetts	alpha 1-Antitrypsin Deficiency	詳細
KB-408	KB-408	Phase 1 Clinical	Krystal Biotech Inc	alpha 1-Antitrypsin Deficiency	詳細
VX-668	VX-668; VX668	Phase 1 Clinical	Vertex Pharmaceuticals Incorporated	alpha 1-Antitrypsin Deficiency	詳細
VX-634	VX-634	Phase 1 Clinical	Vertex Pharmaceuticals Incorporated	alpha 1-Antitrypsin Deficiency	詳細
BMN-349	BMN-349	Phase 1 Clinical	Biomarin Pharmaceutical Inc	alpha 1-Antitrypsin Deficiency	詳細
Alpha-1 antitrypsin (Kalytera Therapeutics)		Clinical	Clalit Health Services		詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Alpha1-proteinase inhibitor (Human, Grifols)	TAL-6004	Approved	Bayer AG, Grifols Sa	Prolastin, Prolastin-c	United States	alpha 1-Antitrypsin Deficiency	null	1987-12-02	alpha 1-Antitrypsin Deficiency; Coronavirus Disease 2019 (COVID-19); Cystic Fibrosis; Pancreatitis, Chronic; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema	詳細
Alfalastin (LFB SA)		Approved	Lfb Biotechnologies Sas	Alfalastin	France	alpha 1-Antitrypsin Deficiency	Lfb Biotechnologies Sas	2005-08-01	alpha 1-Antitrypsin Deficiency	詳細